Results 61 to 70 of about 63,636 (348)

Non-invasive diagnostic and prognostic evaluation of liver cirrhosis and portal hypertension [PDF]

, 2014
Cirrhosis is the final stage of most of chronic liver diseases, and is almost invariably complicated by portal hypertension, which is the most important cause of morbidity and mortality in these patients. This review will focus on the non-invasive methods
Ashkenazi, Eyal, Berzigotti, Annalisa, Bosch i Genover, Jaume, González-Abraldes Iglesias, Juan, Reverter, Enric   +4 more
core   +2 more sources

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

Portal vein thrombosis after laparoscopic splenectomy: an ongoing clinical challenge. [PDF]

, 2005
ObjectivesPortal vein thrombosis (PVT) following open splenectomy is a potentially lethal complication with an incidence of up to 6%. The objective of this report is to describe our management of a recent laparoscopic case, discuss current therapies, and
Kee, Stephen T, Krummel, Thomas M, Mallory, Baird, Miniati, Douglas N, Padidar, Arash M   +4 more
core   +2 more sources

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

A meta-analysis of combined generic-covered stent-graft with or without bare-metal stent for refractory variceal bleeding

Journal of Minimal Access Surgery, 2022
Objectives: The meta-analysis was conducted to systematically assess the efficacy and safety of generic stent-graft/bare-stent combination compared with Fluency stent alone in transjugular intrahepatic portosystemic shunt procedure for refractory ...
Hongcheng Ren, Mingchao Ding, Xiaoyong Huang, Bin Wang, Guoqing Chi, Changgang Shao, Shiyong Song, Wenjie Song, Ruina Shi   +8 more
doaj   +1 more source

Effects of Octapressin on Portal Venous Pressure

Kanzo, 1974
octapressinの門脈圧下降作用を追求する目的で,2例の肝硬変症例および2例の慢性肝炎症例に,同剤の微量緩速点滴静注を行なった.同剤の注入開始後1～2分で閉塞肝静脈圧の下降が始まり,10分以内に減少率14～45%の下降を示した.同剤の注入量は0.4～1.8単位であったが,下降率は注入量に比例せず,むしろ,投与前の閉塞肝静脈圧の高い症例ほど,大きい減少率を示した.末梢動脈血圧は,13～41%上昇し,脈拍数は28～35%減少した.閉塞肝静脈圧は,同剤注入中止後約30分で前値に復した.副作用として,軽度の腹痛,顔面蒼白,尿意を認めたが,格別の処置なく消失した.
Minoru UKIDA, Tatsuya ITOSHIMA, Wataru OHTA, Yoshihiro SHIMADA, Masahiro KUBOTA   +4 more
openaire   +2 more sources

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

National Consensus on Portal Hypertension Management in Indonesia

Acta Medica Indonesiana, 2022
Portal hypertension is a clinical syndrome that consists of hypersplenism, ascites, gastroesophageal varices, and encephalopathy. This condition is marked by increased portal pressure gradient and may occur with or without liver cirrhosis.
Juferdy Kurniawan, Andri Sanityoso Sulaiman, Cosmas Rinaldi Adithya Lesmana, Putut Bayupurnama, Muhammad Begawan Bestari, Fardah Akil, Rino Alvani Gani, Irsan Hasan   +7 more
doaj   +2 more sources

Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis.

PLoS ONE, 2019
BACKGROUND:Prostanoids are important regulators of platelet aggregation and thrombotic arterial diseases. Their involvement in the development of portal vein thrombosis, frequent in decompensated liver cirrhosis, is still not investigated.
Alexander Queck, Dominique Thomas, Christian Jansen, Yannick Schreiber, Sabrina Rüschenbaum, Michael Praktiknjo, Katharina Maria Schwarzkopf, Marcus Maximilian Mücke, Robert Schierwagen, Frank Erhard Uschner, Carsten Meyer, Joan Clària, Stefan Zeuzem, Gerd Geisslinger, Jonel Trebicka, Christian Markus Lange   +15 more
doaj   +1 more source

Innovative application of an implantable venous access system in the portal vein: technique, results and complications in three dogs

BMC Veterinary Research, 2019
Background Vascular access port (VAP) systems are widely used in human medicine to provide long-term venous access. However, in veterinary medicine the use of VAP systems is not common practice and publications on their potential applications have been ...
Kiona S. de Nies, Hedwig S. Kruitwagen, Giora van Straten, Leonie W. L. van Bruggen, Joris H. Robben, Baukje A. Schotanus, Ies Akkerdaas, Anne Kummeling   +7 more
doaj   +1 more source