Results 251 to 260 of about 1,376,217 (363)

Analysis of the growth trajectories of junior residents in Japan: a longitudinal cohort study using data from a nationwide e-portfolio system (EPOC2). [PDF]

open access: yesBMJ Open
Nawa N   +11 more
europepmc   +1 more source

APH Inhibitors that Reverse Aminoglycoside Resistance in Enterococcus casseliflavus

open access: yesChemMedChem, EarlyView.
Molecular dynamics simulations and in silico screening were used to identify non‐competitive inhibitors of APH, the enzymes that confer resistance to aminoglycoside antibiotics. A hit molecule showed activity against APH(2′′)‐IVa. Allosteric inhibition by the hit molecule and a two‐fold more potent analogue was confirmed by enzymatic measurements. Both
Elise Kaplan   +6 more
wiley   +1 more source

Impact of Model‐Informed Drug Development on Drug Development Cycle Times and Clinical Trial Cost

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Model‐informed drug development (MIDD) integrates data to quantify benefit/risk informing objective drug discovery and development decisions. An additional critical benefit of MIDD is postulated to be improvement in trial and program efficiencies. While the application of MIDD has grown, there have been no clear examples across programs to demonstrate ...
Vaishali Sahasrabudhe   +4 more
wiley   +1 more source

Emissions Disclosures and Energy Use Reporting by Hospitals in the United States. [PDF]

open access: yesNAM Perspect
Abel A   +6 more
europepmc   +1 more source

How (Not) to Measure Companies' Climate Transition Risk: A Framework and Categorized Literature Review

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The climate transition is increasingly acknowledged as a major risk driver for companies, financial institutions, and investors. At the same time, there is widespread confusion about how to best measure climate transition risk, since different measurements lead to significantly different risk profiles. I show empirically that, to date, the two
Philip Fliegel
wiley   +1 more source

Home - About - Disclaimer - Privacy