Results 21 to 30 of about 184,985 (319)

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Laparoscopic portosystemic shunt attenuation in two cats

Journal of Feline Medicine and Surgery Open Reports, 2022
Case series summary Gradual attenuation of an extrahepatic portosystemic shunt using cellophane banding was achieved with a laparoscopic technique in two cats.
Francesca Izzo, Edoardo Poggi, Francisco J Pérez Duarte, Filippo Cinti   +3 more
doaj   +1 more source

Progress of pulmonary hypertension and high manganese levels through congenital portosystemic shunt closure

Clinical Case Reports, 2022
A 6‐year‐old girl with congenital portosystemic shunt presented with abnormal manganese levels and improving pulmonary hypertension even 1 year after shunt vascular ligation. As the progress after portal vein blood flow recovery varies among individuals,
Toshihiko Kakiuchi, Yuta Baba, Nobuya Minematsu, Hirohito Doi, Takashi Kumamoto   +4 more
doaj   +1 more source

Percutaneous transhepatic obliteration of a large portosystemic shunt associated with hepatic encephalopathy using a technique of n-butyl-2-cyanoacrylate injection inside hydrogel-coated coils: A case report

Radiology Case Reports, 2022
Portosystemic shunts with cirrhosis may lead to hepatic encephalopathy (HE), which is often pharmacotherapy-resistant. We report a case of a 66-year-old female patient diagnosed with alcoholic cirrhosis and uncontrolled HE.
Yosuke Nozawa, MD, Koichi Masuda, MD, Tadashi Katayama, MD, Yuko Kobashi, MD, PhD, Koshi Ikeda, MD, PhD, Taiga Suzuki, MD, Takeshi Fukuda, MD, PhD   +6 more
doaj   +1 more source

Congenital portosystemic venous shunt [PDF]

European Journal of Pediatrics, 2017
Congenital portosystemic venous shunts are rare developmental anomalies resulting in diversion of portal flow to the systemic circulation and have been divided into extra- and intrahepatic shunts. They occur during liver and systemic venous vascular embryogenesis and are associated with other congenital abnormalities. They carry a higher risk of benign
Michail Pizanias, Nigel Heaton, M. Papamichail   +2 more
openaire   +2 more sources

Transjugular intrahepatic portosystemic shunt in cirrhosis: An exhaustive critical update

World Journal of Gastroenterology, 2020
More than five decades after it was originally conceptualized as rescue therapy for patients with intractable variceal bleeding, the transjugular intrahepatic portosystemic shunt (TIPS) procedure continues to remain a focus of intense clinical and ...
S. Rajesh, Tom George, C. Philips, R. Ahamed, Sandeep V. Kumbar, Narain Mohan, Meera Mohanan, P. Augustine   +7 more
semanticscholar   +1 more source

Transjugular intrahepatic portosystemic shunt in patients with cirrhosis: Indications and posttransjugular intrahepatic portosystemic shunt complications in 2020

United European Gastroenterology journal, 2020
Transjugular intrahepatic portosystemic shunt is a percutaneous radiologic‐guided procedure that aims to reduce portal hypertension by creating a shunt between the portal venous system and the hepatic venous system.
A. Horhat, C. Bureau, D. Thabut, M. Rudler   +3 more
semanticscholar   +1 more source

Transjugular Intrahepatic Portosystemic Shunt [PDF]

Clinics in Liver Disease, 2014
Transjugular intrahepatic portosystemic shunt (TIPS) is an established procedure for the complications of portal hypertension. The largest body of evidence for its use has been supported for recurrent or refractory variceal bleeding and refractory ascites.
Arun J. Sanyal, M.K. Sydnor, Kavish R. Patidar   +2 more
openaire   +3 more sources

Attenuation of congenital portosystemic shunt reduces inflammation in dogs. [PDF]

PLoS ONE, 2015
Liver disease is a major cause of morbidity and mortality. One of the most significant complications in patients with liver disease is the development of neurological disturbances, termed hepatic encephalopathy. The pathogenesis of hepatic encephalopathy
Michael S Tivers, Ian Handel, Adam G Gow, Victoria J Lipscomb, Rajiv Jalan, Richard J Mellanby   +5 more
doaj   +1 more source

The influence of propanolol on portosystemic shunting [PDF]

Hepatology, 1991
We investigated the role of early portal hypotensive pharmacotherapy in preventing the development of portal-systemic shunting in a portal hypertensive model of chronic murine schistosomiasis induced by infecting C3H mice with 60 cercariae of Schistosoma mansoni. Propranolol was administered in drinking water to 20 animals for
Gumucio, Jorge J., Blendis, Laurence M.
openaire   +4 more sources