Results 61 to 70 of about 103,866 (296)

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts

Advanced Science, EarlyView.
MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Huabo Wang, Bingwei Ma, Taylor Stevens, Jessica Knapp, Jie Lu, Edward V. Prochownik   +5 more
wiley   +1 more source

Cæsari in mis omni hora fidelis servivi: The Portraits of Sigismund Herberstein and Walter Leslie in Diplomatic Robes

Radovi Instituta za Povijest Umjetnosti, 2019
This paper discusses the portraits of two imperial ambassadors to the Ottoman Porte, Sigismund Baron Herberstein, who met with Sultan Suleiman the Magnificent in 1541, and Walter Count Leslie, who led the Grand Embassy to Sultan Mehmed IV in 1665–1666 ...
Polona Vidmar
doaj   +1 more source

Pressure‐Induced Ultralow Critical Micelle Concentration of Surfactant for Encapsulating Dye

Advanced Science, EarlyView.
Ultralow critical micelle concentration (CMC) is successfully achieved by pressure. Compared to 917.2 ± 8.7 µm for cetyl trimethyl ammonium bromide at 0.10 MPa, the ultralow CMC at 0.80 GPa is a ≈111‐fold reduction for 8.3 ± 0.1 µm. The detection of ultralow CMC under pressure is owed to the pressure‐induced fluorescence quenching of the coumarin 35 ...
Qi Li, Xinze Liu, Peng Zhu, Meilin Guo, Guangxiong Hu, Jianbo Gao, Cailong Liu, Ying Shi   +7 more
wiley   +1 more source

A Portrait of Pythagoras [PDF]

Papers of the British School at Rome, 1906
The fairly numerous ideal portraits of Homer and the Sages which have come down to us, and the yet more numerous headless herms whose inscriptions bear witness to the frequency of such works in antiquity, naturally suggest that others may exist in our museums representing the more famous rulers and philosophers of the sixtli century, among whom the ...
openaire   +2 more sources

Portraits of Frames [PDF]

Proceedings of the American Mathematical Society, 1995
We introduce two methods for generating frames of a Hilbert space H \mathcal {H} . The first method uses bounded operators on H \mathcal {H} . The other method uses bounded linear operators on l 2 {l_2} to generate frames of H
openaire   +2 more sources

Targeting Glutamine Metabolism Transporter SLC25A22 Enhances CD8+ T‐Cell Function and Anti‐PD‐1 Therapy Efficacy in Cervical Squamous Cell Carcinoma: Integrated Metabolomics, Transcriptomics and T‐Cell‐Incorporated Tumor Organoid Studies

Advanced Science, EarlyView.
Through metabolomic and transcriptomic analyses, a glutamine‐enriched, immunosuppressive microenvironment is identified in cervical squamous cell carcinoma (CSCC), highlighting the glutamine transporter SLC25A22 as a key regulator of glutamine metabolism, immune checkpoint activation, and CD8+ T‐cell cytotoxicity.
Tingting Ren, Junjun Qiu, Fanghua Chen, Qian Jiang, Qinqin Liu, Tong Wu, Hua Jiang, Keqin Hua   +7 more
wiley   +1 more source

Didáctica del dibujo de contornos ciegos aplicada al retrato gráfico = Teaching the blind contours drawing applied to graphic portrait

Arte, Diseño e Ingeniería, 2016
Resumen En el área de la enseñanza del Dibujo Artístico, el retrato es una de las temáticas más complejas e interesantes a las que un estudiante debe enfrentarse.
Ignacio Martínez de Salazar Muñoz, Pedro Javier Albar Mansoa   +1 more
doaj  

Mechanical Metamaterial‐Based Structure with Magnetically Controlled Nonreversibility and Nonreciprocity for Programmable Locomotion

Advanced Science, EarlyView.
A magneto‐mechanical metamaterial‐based structure that simultaneously exhibits programmable nonreversibility and nonreciprocity. These cause substantial transitions in static mechanical properties, such as Poisson's ratio and stiffness, leading to stark changes in energy absorption.
Krzysztof K. Dudek, Olly Duncan, Julio A. Iglesias Martínez, Muamer Kadic   +3 more
wiley   +1 more source