Results 41 to 50 of about 608,615 (263)

Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms

Advanced Functional Materials, EarlyView.
Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger, Min Jiang, Florian Belger, Fabian Link, Benjamin Winkeljann, Olivia M. Merkel   +5 more
wiley   +1 more source

Exploring a parameterised portrait painting space

International Journal of Arts and Technology, 2009
We overview our interdisciplinary work building parameterised knowledge domains and their authoring tools that allow for expression systems, which move through a space of painterly portraiture. With new computational systems it is possible to conceptually dance, compose and paint in higher-level conceptual spaces.
openaire   +2 more sources

Unlocking Terahertz Steganography: Authentication of Hidden Images in Flexible Media

Advanced Materials Technologies, EarlyView.
Hidden information in multilayered devices, such as steganographic portraits, is detected and authenticated using reflection‐mode terahertz time‐domain imaging. Image reconstruction relies on a dedicated figure‐of‐merit obtained by integrating the signal intensity over the time‐window associated with the reflection from the metallic mirror backing the ...
Tiziana Ritacco, Francesca Vittorioso, Dimitrios C. Zografopoulos, Romeo Beccherelli, Walter Fuscaldo   +4 more
wiley   +1 more source

Zero‐Waste Manufacturing of Ophthalmic Lenses by Direct Fluidic Shaping in Arbitrary Domains

Advanced Materials Technologies, EarlyView.
Conventional ophthalmic lens manufacturing discards up to 97% of material through subtractive processes. The Cookie Cutter algorithm extends Fluidic Shaping to arbitrary rim geometries. The framework prescribes a spatially varying boundary height that, under neutral buoyancy and surface tension, shapes curable polymer into spherocylindrical lenses that
Yotam Katzman, Mor Elgarisi, Amos A. Hari, Jonathan Ericson, Omer Luria, Valeri Frumkin, Moran Bercovici   +6 more
wiley   +1 more source

Continuum Robots in Surgery: From Engineering Design to Clinical Practice

Advanced Robotics Research, EarlyView.
The hyper‐redundant nature of continuum robot structures enables near‐infinite degrees of freedom leading to immense potential for medical applications. This review provides a historical background of continuum robots and novel ideas shaping their progress to current structural design, sensing technology, modeling techniques, and control methods.
Griffin Smith, Kaitlyn Clancy, Siwen Xie, Xiaochen Li, Sarah Khalife, Benjamin van der Woerd, Onaizah Onaizah   +6 more
wiley   +1 more source

Young children's perspectives of time: New directions for co‐constructing understandings of quality in ECEC

British Educational Research Journal, EarlyView., 2023
Abstract Children's relationship with time in preschools is an under‐researched area. Young children rarely know how to measure time using a clock, but their experiences of time may contribute to understanding children's well‐being and debates about quality in preschools.
Kristín Dýrfjörð, Anna Magnea Hreinsdóttir, Adrijana Visnjic‐Jevtic, Alison Clark   +3 more
wiley   +1 more source

Kazimir Malevich, Maria Dzhagupova and a Contested Portrait of Elizaveta Iakovleva

Arts
This essay examines the painting known as Portrait of Elizaveta Iakovleva, which has long been attributed to Kazimir Malevich, using close analysis of the painting materials and techniques, as well as newly discovered archival evidence.
Alexander Lisov, Willem Jan Renders
doaj   +1 more source

Analog Synaptic Plasticity in 2D Layered Material Iontronic Memtransistors for Brain‐Inspired Computing

Advanced Science, EarlyView.
In this work, we demonstrated a robust 2D MoS2 based iontronic memtransistor of planar architecture operated under the influence of an electrical double layer with versatile performance and applications, including pinched hysteresis nature of transfer curve, analogue channel conductance tuning, low‐voltage operation, logic‐gate operation, classical ...
Puranjay Saha, Saptarshi Bej, Bikas C. Das   +2 more
wiley   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source