Results 171 to 180 of about 2,099,616 (290)

Do drugs approved via expedited approval pathways have therapeutic advantages? A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer, Eliza J. McEwin, Zhicheng Wang, Joel Lexchin, Barbara Mintzes   +4 more
wiley   +1 more source

Jejunal adenocarcinoma with isolated mesorectal metastasis: a case report of a rare entity. [PDF]

J Surg Case Rep
Corte-Real F, Catarino S, Sá M, Valério F, Pereira J.   +4 more
europepmc   +1 more source

Ocrelizumab‐induced colitis: VigiBase disproportionality analysis, case reports and literature review

British Journal of Clinical Pharmacology, EarlyView.
Aims Ocrelizumab is a humanized anti‐CD20 monoclonal antibody used in multiple sclerosis. Since its commercialization, several cases of ocrelizumab‐induced colitis have been reported in the scientific literature. Methods To explore the potential association of ocrelizumab with colitis as an adverse drug reaction (ADR), we conducted a descriptive and ...
Audrey Fresse, Christophe Hommel, Nadine Petitpain, Philippe Kerschen   +3 more
wiley   +1 more source

Early GH therapy and neurodevelopmental outcome in a child with compound heterozygous <i>IGF1R</i> variants. [PDF]

JCEM Case Rep
Sá Pinto M, Oliveira M, Ferrão T, Ramos F, Cardoso R, Leite AL.   +5 more
europepmc   +1 more source

Empowering citizens to spontaneously report suspected adverse drug reaction: Systematic literature review of interventions and their impact

British Journal of Clinical Pharmacology, EarlyView.
This systematic literature review aimed to identify and characterize existing interventions designed to empower citizens to spontaneously report adverse drug reactions (ADRs) and to determine which interventions have been shown to be the most effective internationally. The research question was structured using the PICO framework.
Margarida Perdigão, Ana Margarida Advinha, Manuel José Lopes, Sofia de Oliveira Martins   +3 more
wiley   +1 more source

Meeting abstracts of the NursID Spring School 2025. [PDF]

BMC Proc
europepmc   +1 more source

Long-Term Outcomes of Low-Dose-Rate Brachytherapy in Localized Prostate Cancer: A 17-Year Retrospective Analysis of a Single-Center Portuguese Cohort. [PDF]

J Clin Med
Rabaça C, Roda D, Vieira G, Pereira B, Godinho R, Lourenço M, Pereira JA, Regencio M, Macedo S, Sismeiro A.   +9 more
europepmc   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Correction to "Multigene Germline Panel Testing in Gastric Cancer Patients in a Portuguese Population". [PDF]

Cancer Med
europepmc   +1 more source

Genoprotective Properties of <i>Cedrus atlantica</i> Essential Oil: Evidence from the Comet Assay. [PDF]

Int J Mol Sci
Gonçalves SD, Silva C, Diogo RG, Chyczij F, Esteves V, Miranda N, Tkach VV, Gaivão I, Caramelo A.   +8 more
europepmc   +1 more source