Results 81 to 90 of about 550,284 (290)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Temporal channel reconfiguration multi‐graph convolution network for skeleton‐based action recognition

IET Computer Vision
Skeleton‐based action recognition has received much attention and achieved remarkable achievements in the field of human action recognition. In time series action prediction for different scales, existing methods mainly focus on attention mechanisms to ...
Siyue Lei, Bin Tang, Yanhua Chen, Mingfu Zhao, Yifei Xu, Zourong Long   +5 more
doaj   +1 more source

A Novel Method for the Absolute Pose Problem with Pairwise Constraints

, 2019
Absolute pose estimation is a fundamental problem in computer vision, and it is a typical parameter estimation problem, meaning that efforts to solve it will always suffer from outlier-contaminated data.
Chen, Guang, Knoll, Alois, Li, Xuechen, Liu, Yinlong, Song, Zhijian, Wang, Manning   +5 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Fast Single Shot Detection and Pose Estimation

, 2016
For applications in navigation and robotics, estimating the 3D pose of objects is as important as detection. Many approaches to pose estimation rely on detecting or tracking parts or keypoints [11, 21]. In this paper we build on a recent state-of-the-art
Ammirato, Phil, Berg, Alexander C., Fu, Cheng-Yang, Kosecka, Jana, Liu, Wei, Poirson, Patrick   +5 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

PRAMGCN-Net: 3D Human Pose Estimation With a Parameterized Routing Adjacency Modulation Graph Convolutional Network

IEEE Access
Human pose estimation reconstructs 3D human joint positions from monocular images or videos, enabling applications in healthcare, sports, AR/VR, and animation. The challenge lies in depth ambiguity, temporal coherence, and complex motion patterns. Recent
Andy Pramono, I-Cheng Chang, Betty Dewi Puspasari   +2 more
doaj   +1 more source

Compositional Human Pose Regression

, 2017
Regression based methods are not performing as well as detection based methods for human pose estimation. A central problem is that the structural information in the pose is not well exploited in the previous regression methods.
Liang, Shuang, Shang, Jiaxiang, Sun, Xiao, Wei, Yichen   +3 more
core   +1 more source

Generalised Pose Estimation Using Depth [PDF]

, 2012
Estimating the pose of an object, be it articulated, deformable or rigid, is an important task, with applications ranging from Human-Computer Interaction to environmental understanding. The idea of a general pose estimation framework, capable of being rapidly retrained to suit a variety of tasks, is appealing.
Hadfield, Simon, Bowden, Richard
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source