Results 41 to 50 of about 38,700 (289)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

CREDIT SOLVENCY OF AGRICULTURAL COMPANY AS A FACTOR OF QUALITY MARKET POSITION

open access: yesEkonomika Poljoprivrede (1979), 2006
The main target of agriculture is to make the profit and the food production represents the function of agriculture. The economic and financial strength of agriculture system –producers is main paramether market position and verification in conditions ...
Aleksandar Vasiljevic, Nebojsa Novkovic
doaj  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

SIX SIMPLE PROPOSITIONS ON BUDGET DEFICITS, PUBLIC DEBT AND MONEY

open access: yesCadernos CEPEC, 2018
The paper sets out and elaborates on six propositions on budget deficits, public debt and money which should inform debates on fiscal policy. The propositions are: Money availability is not a limitation on government expenditure as the central bank is
Malcolm Sawyer
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

KEDUDUKAN MENTERI KEUANGAN DALAM KEPAILITAN PERUSAHAAN ASURANSI

open access: yesJurnal Media Hukum, 2015
The research is aimed at investigating the exclusive position of the Minister of Finance as an applicant in an insurance company’s bankruptcy. This given authority has brought up issues in relation to law particularly concerning principle obedience ...
Djoko Imbawani Atmadjaja, Anwar Anwar
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Inclusive Finance of China: The Practice of Postal savings bank of China

open access: yesФинансы: теория и практика
This article reveals the nature and economic essence of a bank within the system of financial relations with the state and society. The bank is considered as an intermediary in the conduct of entrepreneurial activities from the perspective of fulfilling ...
L. A. Mezentseva
doaj   +1 more source

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