Results 101 to 110 of about 1,182,692 (300)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Comment on Position Statements [PDF]

Diabetes Care, 1987
F J, Service, R A, Rizza, B R, Zimmerman
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Position Statement about Gender-Neutral HPV Vaccination in Korea

Vaccines
Given the rising incidence of human papillomavirus (HPV)-related diseases, including cervical, penile, and oropharyngeal cancers, particularly among men, the implementation of comprehensive HPV vaccination strategies is necessary in South Korea.
Kyung-Jin Min, Yung-Taek Ouh, Sangrak Bae, Yong-Bae Ji, Jae-Kwan Lee, Jae-Weon Kim, Kwang-Jae Cho, Dong-Hun Im   +7 more
doaj   +1 more source

Big Thicket Association Position Statement

, 1975
Position Statement issued by the Big Thicket Association regarding House Resolutions 2554 and ...
Big Thicket Association
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Consensus document on frailty: conceptualization, detection, multidisciplinary management and future roadmap

The Journal of Nutrition, Health and Aging
Background: The lack of a universally accepted definition, a gold-standard assessment tool, and sufficient evidence-based interventions has hindered the integration of frailty into routine clinical practice, particularly outside geriatric medicine.
Alejandro Álvarez-Bustos, Cristina Andres-Lacueva, Ignacio Ara, María Angeles Arévalo, Juan P. Bolaños, Ana Coto-Montes, José Antonio Enriquez, Germaine Escames, Francisco José García-García, María Carmen Gómez-Cabrera, Oriol Grau-Rivera, Mikel Izquierdo, Nicolás Martínez Velilla, Ander Matheu, Rocío Menéndez Colino, Manuel Muñoz Torres, Xavier Nogués, Juan Oliva, María Isabel Orts-Cortés, Ignacio Párraga Martínez, Feliciano Priego, Montserrat Rabassa-Bonet, María Ángeles Rol, José Antonio Serra-Rexach, Francisco José Tarazona-Santabalbina, Leocadio Rodríguez-Mañas, Pedro Abizanda   +26 more
doaj   +1 more source

Daring to Lead : Global perceptions of the IFHE Position Statement "Home Economics in the 21st Century" [PDF]

, 2009
Peer ...
Pendergast, Donna, Dewhurst, Yvonne
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source