Results 161 to 170 of about 104,748 (300)

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Cheyne-Stokes respiration detected via CPAP devices as a digital biomarker for heart failure in obstructive sleep apnoea: systematic review. [PDF]

Sleep Adv
Mutombe NM, Ekanayake K, Chow CM.
europepmc   +1 more source

Effect of ceftriaxone on blood pressure, respiration and its analgesic and antipyretic activities [PDF]

Aim: The aim of this study was to determine the effect of ceftriaxone on blood pressure and respiration in dog. In addition, analgesic and antipyretic activities of ceftriaxone were investigated in mice and rats.
Mohamed Aboubakr, Mossad Elsayed, Ashraf Elkomy   +2 more
core  

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Impact of noradrenaline, adrenergic receptors, and radical formation on cardiac mitochondria in resuscitated swine. [PDF]

Intensive Care Med Exp
Abele N, Merz T, Zink F, Hoffmann A, Gröger M, Kress S, Kranz S, Seifritz A, Passarelli V, Münz F, Feth M, Scheer M, Sharon O, Hogg M, Wolfschmitt EM, Wachter U, Schulz T, Calzia E, Fage N, Waller C, Asfar P, Radermacher P, Kapapa T.   +22 more
europepmc   +1 more source

Spontaneous breathing with continuous positive airway pressure in adult respiratory distress syndrome.

, 1978
peer reviewedThe authors describe three systems of spontaneous respiration with positive end expiratory pressure (P.E.E.P.) : the system of continuous positive airway pressure (C.P.A.P.), the bubble and the intermittent mandatory ventilation with C.P.A.P.
Lamy, Maurice, Piette, Ch
core  

Hydrogen (H2) Recovery From Hydrogen Sulfide (H2S): Current Technologies, Challenges, and Future Outlook

Advanced Science, EarlyView.
ABSTRACT Hydrogen sulfide (H2S) can be transformed into hydrogen (H2) through several chemical and catalytic processes, offering a promising route for both waste treatment and clean H2 production. This colorless, flammable, and toxic gas is found abundantly in swamps, volcanoes, hot springs, sewages, other natural gas fields, and even in refineries and
Divyesh Cirikonda, Astrid Campos‐Mata, Sehmus Ozden, Shreyasi Chattopadhyay, Pulickel M. Ajayan   +4 more
wiley   +1 more source

Seated Sedation-Analgesia With Preserved Spontaneous Ventilation to Facilitate Intubation After Transition to the Supine Position: A Case Report. [PDF]

Cureus
Tagawa R, Shakuo T, Yamazaki Y, Masunaga N, Shida K.   +4 more
europepmc   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

In vivo quantification of mitochondrial O₂ affinity in human skeletal muscle using ¹H-magnetic resonance spectroscopy of deoxy-myoglobin. [PDF]

J Physiol
Erol ME, Matias AA, Serviente CF, Decker ST, Nagarajan R, Ramadan S, Fur YL, Park SY, Layec G.   +8 more
europepmc   +1 more source