Results 61 to 70 of about 7,373,496 (288)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Sleep Apnea and Aortic Dissection

Canadian Respiratory Journal, 1995
A 62-year-old man presented with obstructive sleep apnea, congestive heart failure and Cheyne-Stokes respiration. Further evaluation revealed a chronic dissecting aneurysm of the aorta causing vena caval obstruction.
Patrick J Hanly, David Ford
doaj   +1 more source

Monitoring respiration using the pressure sensors in a dialysis machine [PDF]

, 2019
OBJECTIVE: Although respiratory problems are common among patients with end-stage renal disease, respiration is not continuously monitored during dialysis. The purpose of the present study is to investigate the feasibility of monitoring respiration using
Sandberg, Frida, Olde, Bo, Holmer, Mattias   +2 more
core   +1 more source

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio   +5 more
wiley   +1 more source

Continuous positive airway pressure (CPAP) after lung resection: a randomized clinical trial

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Noninvasive mechanical ventilation during the postoperative period (PO) following lung resection can restore residual functional capacity, improve oxygenation and spare the inspiratory muscles.
Ligia dos Santos Roceto, Fernanda Diorio Masi Galhardo, Ivete Alonso Bredda Saad, Ivan Felizardo Contrera Toro   +3 more
doaj   +1 more source

The effects of anesthesia induction and positive pressure ventilation on right-ventricular function: an echocardiography-based prospective observational study

BMC Anesthesiology, 2019
Background General anesthesia induction with the initiation of positive pressure ventilation creates a vulnerable phase for patients. The impact of positive intrathoracic pressure on cardiac performance has been studied but remains controversial.
Harry Magunia, Anne Jordanow, Marius Keller, Peter Rosenberger, Martina Nowak-Machen   +4 more
doaj   +1 more source

Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli, Karine Lacourse, Hélène Blais, Anne‐Sophie Deshaies‐Rugama, Cynthia Thompson, Alex Desautels, Jacques Montplaisir, Milan Nigam, Christophe Moderie, Boshra Khajehpiri, Catherine Duclos, Jean Marc Lina, Julie Carrier, Nadia Gosselin   +13 more
wiley   +1 more source

Knowledge and experience of physiotherapists on non-invasive ventilation [PDF]

Revista Brasileira em Promoção da Saúde, 2011
Objective: To compare knowledge and experience in non-invasive ventilation (NIV) among physiotherapists of hospital wards and adult Intensive Care Units (ICU).
Isabel Cristina de Mendonça Santiago, Fabíola Maria Sabino Meireles, Cymara Pessoa Kuehner, Mirizana Alves-de-Almeida   +3 more
doaj  

Influence of expiratory positive airway pressure on cardiac autonomic modulation at rest and in submaximal exercise in COPD patients

Brazilian Journal of Medical and Biological Research, 2018
The aim of this study was to evaluate the effect of expiratory positive airway pressure (EPAP) on heart rate variability (HRV) indices at rest and during 6-min walk test (6MWT) in chronic obstructive pulmonary disease (COPD) patients. Fifteen moderate to
C. da L. Goulart, E.A. San Martin, K.M.K. Mansour, P.B. Schneiders, A.L.G. da Silva   +4 more
doaj   +1 more source

Capnothorax During Laparoscopy in Trendelenburg Position: A Rare Case Study

Acta Médica Portuguesa, 2020
Pneumothorax is an infrequent complication of laparoscopic surgery. Most cases occur during upper abdominal surgery, since a head-down position (Trendelenburg) pushes the liver and peritoneum against the diaphragm, reducing gas release.
Ana Margarida Damas, Fátima Gonçalves, Marisa Antunes, Sónia Barata   +3 more
doaj   +1 more source