Results 121 to 130 of about 9,419,615 (268)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Transcultural psychotherapy and positive psichology: an integrated model

open access: yes, 2008
This intervention aims to expose a clinical approach that melts theories and practices taken from transcultural psychology and psychotherapy and theories and instruments coming from the field of positive psychology. Among the clinicians of transcultural
E. F. M. Riva
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Positive Pattern

open access: yes, 2016
A series of 5 sculptures, which reproduce in positive form by means of laser scanning and CNC-milling in rigid foam, the interior ‘negative’ spaces of 5 carved wooden, original Barbara Hepworth sculptures. Research aims: 1.
Borland, Christine
core  

Surgeon interpretation of margin status utilizing intraoperative 3D tomosynthesis during breast-conserving surgery. [PDF]

open access: yesBreast Cancer Res Treat
Leonard LD   +14 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Positive Me Positive Kid

open access: yes, 2019
Help parents understand the benefits of positive thinking; help parents build a positive parenting attitude, set reasonable expectation and rules with children, avoid over-training and overscheduling children’s learning, as well as avoid comparing their ...
Liu, SHS
core  

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