Results 161 to 170 of about 9,419,615 (268)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Rheumatoid factor and anticitrullinated protein antibody status jointly influence the association between disease activity and cardiovascular risk in rheumatoid arthritis. [PDF]

RMD Open
Karpouzas GA, Gonzalez-Gay MA, Pascual-Ramos V, Misra DP, Myasoedova E, Rantapää-Dahlqvist S, Sfikakis P, Dessein P, Hitchon CA, Galarza-Delgado D, Van Riel P, Semb AG, Hauge EM, Kitas GD, Ormseth SR, for An inTernationAl Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA).   +15 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Correction to: Molecular analysis of AmpC-producing Escherichia coli isolated from pediatric patients. [PDF]

J Pediatric Infect Dis Soc
europepmc   +1 more source

Performance and Cost-Efficiency of an MPT64 Assay for Detecting <i>Mycobacterium tuberculosis</i> Complex in a Setting With Frequent Nontuberculous Mycobacteria Isolation. [PDF]

J Korean Med Sci
Yu HJ, Kim JA, Song HM, Lee KA, Kim H, Yoo IY, Kim TY, Huh HJ.   +7 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Minimally acceptable criteria and required sample size for an accuracy study of non-invasive prenatal testing of sickle cell disease in screen positive women in England: results of a decision tree model. [PDF]

Diagn Progn Res
Vardanega V, Bobrowska A, Ruban-Fell B, Doorbar JA, Lombardo S, Seedat F, Daniel Y, Hogan A, Leeflang MMG, Mann K, Schuh A, Marshall J.   +11 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Screening 1021 Swedish memory clinic visitors for autoantibody-mediated encephalitis. [PDF]

J Neurol
Freitas-Huhtamäki A, Kleebauer N, Gardner A, Lundberg J, Esbjörnsson M, Da Silva Rodrigues R, Waters P, Scheller-Nissen M, Blaabjerg M, Bogdanovic N, Theorell J.   +10 more
europepmc   +1 more source