Results 71 to 80 of about 9,419,615 (268)
Lapatinib in the Treatment of Hormone Receptor-Positive/ErbB2-Positive Breast Cancer [PDF]
, 2010 In women with estrogen receptor(ER)- and ErbB2(HER2)-positive breast cancer, a vicious cycle is established between ER mechanisms of action and the growth factor receptor network, leading to enhanced cell proliferation and endocrine resistance.
Bauerfeind, Ingo +2 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hemodynamic effects of positive inotropes
, 2022 The hemodynamic effects of positive inotropes in acute heart failure are described in this thesis, the inportant aspects of the effects are explained and Comparison of the mortality rates are emphasized.általános orvosangolegységes ...
Namdari, Parsa
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Nature-Positive Solutions and CGIAR: A pop up exhibit
Nature-Positive Solutions and CGIAR is a pop-up art exhibition featuring information artworks produced in collaboration with The Lexicon of Sustainability and the CGIAR Nature-Positive Solutions Initiative.
CGIAR Nature-Positive Solutions Initiative +1 more
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Positive Action in the United Kingdom [PDF]
, 2010 YesThis paper provides an overview of the laws regulating positive action in the UK. It also presents key findings from a selection of research studies on positive action in the UK conducted between 2003 and 2009 by the Centre for Inclusion and Diversity
Ashraf, Fahmida, Archibong, Uduak E.
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Positive expressive technologies for social wellness
, 2009 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Drawing on research from the fields of HCI, social and positive psychology, this thesis investigates the design of technologies that encourage the ...
Kanis, Marije
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On positive-realness and stability of switched linear differential systems
, 2013 We present some results regarding the stability of switched linear differential systems (SLDS) in the behavioral framework. Positive-realness is studied as a sufficient condition for stability and some implications derived from the use of positive-real ...
Paolo Rapisarda +3 more
core +1 more source