Results 151 to 160 of about 6,360,215 (357)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

The Effectiveness of Reality Therapy Training on Marital Burnout in Couple with Marital Conflicts

open access: yesTaḥqīqāt-i ̒Ulūm-i Raftārī, 2020
Aim and Background: Love is one of the most amazing emotions a person can experience and emotional failure is one of the most painful problems that can happen to anyone during a romantic relationship.
Raziye Aminalsadat   +3 more
doaj  

Number of hemoccult windows positive affects work-up

open access: bronze, 1998
H. Shields   +7 more
openalex   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Bem-estar subjetivo: aspectos conceituais

open access: yesArquivos Brasileiros de Psicologia, 2014
It can be depicted from the analyses of publications in the topic Subjective Well-Being (SWB), that SWB/happiness is perceived as: a) trait; b) state; or c) "being in charge of his/her own life", according to different groups of authors.
Luiza Santos Moreira da Costa   +1 more
doaj  

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