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Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi+3 more
wiley +1 more source
A nod in the wrong direction : Does nonverbal feedback affect eyewitness confidence in interviews? [PDF]
Eyewitnesses can be influenced by an interviewer's behaviour and report information with inflated confidence as a result. Previous research has shown that positive feedback administered verbally can affect the confidence attributed to testimony, but the ...
Daniel J. Gurney+7 more
core +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
The aim of this article was to validate and compare the Dutch translations of the Gratitude Questionnaire (GQ6) and the Short Gratitude, Resentment, and Appreciation Test (SGRAT) in an adult general population sample. In an online survey, 706 respondents
Lilian Jans-Beken+3 more
doaj +1 more source
Emotional intelligence and satisfaction at work in teachers: Testing affectivity as potential mediator. [PDF]
Introduction: Although previous research has highlighted the role of emotional intelligence on satisfaction at work, the underlying processes accounting for this association remain relatively unexplored.
Extremera, Natalio+2 more
core
Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Emotion regulation strategies and aggression in youngsters: The mediating role of negative affect
Aggression in youngsters is a highly prevalent problem worldwide. Given that this problem has negative consequences for society, aggressors, and victims, the present study aims to understand the processes underlying the acts of aggression in this ...
María José Gutiérrez-Cobo+4 more
doaj
There is abundant empirical evidence on the negative effects of discrimination on psychological well-being. However, little research has focused on exploring the factors that can mitigate this effect. Within this framework, the present study examined the
Alfonso Urzúa+2 more
doaj +1 more source
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa+8 more
wiley +1 more source
The Multidimensional Perfectionism Cognitions Inventory–English (MPCI-E): Reliability, validity, and relationships with positive and negative affect [PDF]
The Multidimensional Perfectionism Cognitions Inventory (MPCI; Kobori & Tanno, 2004) is a promising new instrument developed in Japan to assess perfectionism cognitions regarding personal standards, pursuit of perfection, and concern over mistakes.
Kobori, Osamu+2 more
core +1 more source