Results 81 to 90 of about 46,379 (263)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Extreme programming and its positive affect on software engineering teams [PDF]
, 2009 This paper presents an early empirical study on Extreme Programming (XP) practices employing Positive Affect metric.The study was conducted on university students doing development projects to gain an insight understanding of the effect of using agile ...
Omar, Mazni +1 more
core
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
A cross-lagged model of reinforcement sensitivity, personality and affectivity
Current Issues in Personality Psychology, 2017 Background There is a rich body of literature describing the links between behavioral activation/inhibition, personality and trait affectivity. The sensitivity of the behavioral activation system (BAS) is related to extraversion and positive affect ...
Blaž Rebernjak, Vesna Buško
doaj +1 more source
Depresión y ansiedad en mujeres con cáncer de mama: el papel de la afectividad y el soporte social [PDF]
OBJECTIVE: To establish the relationship between affectivity and social support profile and the presence and severity of depression and anxiety among women with breast cancer.
Jiménez, Luz Margarita +3 more
core +1 more source
The Effect of Dysfunctional Thought Processes on Subjective Well-Being and Job Satisfaction [PDF]
, 1992 While the dispositional approach to job satisfaction has received a good deal of recent attention, a fundamental deficiency in past dispositional research is a failure to use existing theories to explain why individuals are unhappy and dissatisfied with ...
Judge, Timothy A., Locke, Edwin A.
core +1 more source
Heidegger’s 1924 Clearing of the Affects Using Aristotle’s Rhetoric, Book II [PDF]
, 2010 Heidegger famously said that the best treatment of the emotions in western history was Book 2 of Aristotle's RHETORIC. Heidegger then did an analysis of this material prior to the publication of Being and TIme (1927).
Agosta, Lou
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source