Results 271 to 280 of about 5,889,360 (355)

A probabilistic diagnostic for Laplace approximations: Introduction and experimentation

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Many models require integrals of high‐dimensional functions: for instance, to obtain marginal likelihoods. Such integrals may be intractable, or too expensive to compute numerically. Instead, we can use the Laplace approximation (LA). The LA is exact if the function is proportional to a normal density; its effectiveness therefore depends on ...
Shaun McDonald, Dave Campbell
wiley   +1 more source

Predicting cervical cancer DNA methylation from genetic data using multivariate CMMP

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Epigenetic modifications link the environment to gene expression and play a crucial role in tumour development. DNA methylation, in particular, is gaining attention in cancer research, including cervical cancer, the focus of this study.
Hang Zhang   +5 more
wiley   +1 more source

Coumarin‐Caged Nanoparticle for Light‐Driven Surface Modification

open access: yesChemMedChem, EarlyView.
Photo‐responsive nanoparticles (NPs) enable spatiotemporal control over drug delivery. Attachment of a photo‐labile protecting group (PPG) to cell‐penetrating peptide (CPP) effectively camouflages the positive charge of NPs. Light irradiation cleaves the PPG, exposing the CPP on the NP surface and thereby enhancing cellular uptake.
Jan Birringer   +4 more
wiley   +1 more source

A priori estimates and large population limits for some nonsymmetric Nash systems with semimonotonicity

open access: yesCommunications on Pure and Applied Mathematics, EarlyView.
Abstract We address the problem of regularity of solutions ui(t,x1,…,xN)$u^i(t, x^1, \ldots, x^N)$ to a family of semilinear parabolic systems of N$N$ equations, which describe closed‐loop equilibria of some N$N$‐player differential games with Lagrangian having quadratic behaviour in the velocity variable, running costs fi(x)$f^i(x)$ and final costs gi(
Marco Cirant, Davide Francesco Redaelli
wiley   +1 more source

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