Results 271 to 280 of about 5,774,152 (370)

Weighing risks against GHG reduction benefits in emerging green technologies

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
Abstract Green technologies represent promising strategies for mitigating carbon emissions and combating global warming. However, their implementation in civil and industrial applications is not without risks, as intrinsic uncertainties and latent safety concerns can threaten their effective deployment.
Federica Tamburini   +3 more
wiley   +1 more source

Tangent space functional reconfigurations in individuals at risk for alcohol use disorder. [PDF]

open access: yesNetw Neurosci
Moghaddam M   +8 more
europepmc   +1 more source

Uniqueness on average of large isoperimetric sets in noncompact manifolds with nonnegative Ricci curvature

open access: yesCommunications on Pure and Applied Mathematics, EarlyView.
Abstract Let (Mn,g)$(M^n,g)$ be a complete Riemannian manifold which is not isometric to Rn$\mathbb {R}^n$, has nonnegative Ricci curvature, Euclidean volume growth, and quadratic Riemann curvature decay. We prove that there exists a set G⊂(0,∞)$\mathcal {G}\subset (0,\infty)$ with density 1 at infinity such that for every V∈G$V\in \mathcal {G}$ there ...
Gioacchino Antonelli   +2 more
wiley   +1 more source

Boundary conditions and universal finite‐size scaling for the hierarchical |φ|4$|\varphi |^4$ model in dimensions 4 and higher

open access: yesCommunications on Pure and Applied Mathematics, EarlyView.
Abstract We analyse and clarify the finite‐size scaling of the weakly‐coupled hierarchical n$n$‐component |φ|4$|\varphi |^4$ model for all integers n≥1$n \ge 1$ in all dimensions d≥4$d\ge 4$, for both free and periodic boundary conditions. For d>4$d>4$, we prove that for a volume of size Rd$R^{d}$ with periodic boundary conditions the infinite‐volume ...
Emmanuel Michta   +2 more
wiley   +1 more source

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano   +8 more
wiley   +1 more source

Dose Selection for DuoBody®‐CD40x4‐1BB (GEN1042/BNT312) Using a mPBPK/RO Model Leveraging Preclinical and Clinical Data

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Optimizing target engagement for bispecific antibodies (bsAbs) is challenging, as bsAbs bind to two different targets in vivo to form a trimolecular complex (trimer), and likely display a bell‐shaped concentration–response curve. bsAbs trimer formation is expected to be related to efficacy and safety, and determining the dose level at which it is ...
Gaurav Bajaj   +16 more
wiley   +1 more source

Epitaxy and Topotaxy in the Aragonite‐Calcite Polymorphism

open access: yesCrystal Research and Technology, EarlyView.
At first distinguish epitaxy from topotaxy, which rule the main mechanisms of calcite‐aragonite transitions. Then, attempt to move from qualitative to quantitative descriptions of these transitions. Hence, it will deal with 2D (epitaxy) and 3D (topotaxy) conversions in the polymorphic system, in order to gain insight on their differences.
D. Aquilano   +3 more
wiley   +1 more source

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