Results 221 to 230 of about 3,784,145 (318)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Impacts of Maternal Nutrition on Sow Performance and Potential Positive Effects on Piglet Performance. [PDF]

Animals (Basel)
Gormley A, Jang KB, Garavito-Duarte Y, Deng Z, Kim SW.   +4 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Positive effects of diet-induced microbiome modification on GDM in mice following human faecal transfer. [PDF]

Gut
Frishman S, Nuriel-Ohayon M, Turjeman S, Pinto Y, Yariv O, Tenenbaum-Gavish K, Peled Y, Poran E, Pardo J, Chen R, Muller E, Borenstein E, Hod M, Louzoun Y, Schwartz B, Hadar E, Collado MC, Koren O.   +17 more
europepmc   +1 more source

The Healing Power of the Ocean : the Positive Effects of Ocean Environments on Health and Wellbeing

Anja Ising, Zsófia Kerényi, Mariana Becker, Jelena Tomičević-Dubljević, Lena Lidfors, Anna María Pálsdóttir   +5 more
openalex   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Corrigendum: Positive effects of Cordyceps cateniannulata colonization in tobacco: growth promotion and resistance to abiotic stress. [PDF]

Front Microbiol
Qiao L, Liu J, Zhou Z, Li Z, Zhou Y, Xu S, Yang Z, Qu J, Zou X.   +8 more
europepmc   +1 more source

Temperature and pressure effects on the properties of positive streamers in air

, 2012
T. Huiskamp, van Ejm Bert Heesch, Fjcm Frank Beckers, Wflm Wilfred Hoeben, Ajm Guus Pemen   +4 more
openalex   +1 more source

The Effects of Positive Psychological Traits on Negative Feelings, and their Relationships with the Top and Bottom Brain Systems

Naoki Shibahara, Masao Endo, Yoshiyuki Izawa, Mieko Naoshima, Hiromu Nagaura, Tomoyuki Hisa   +5 more
openalex   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source