Results 221 to 230 of about 10,377,024 (298)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Meta-Analysis of Psychological and Digital Interventions to Enhance Mental Health and Well-Being in Youth: A Bayesian Umbrella Review. [PDF]

Children (Basel)
Sánchez-Álvarez N, Blanca MJ, Sánchez-Meca J.   +2 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Controlling memorability of face images with generative models. [PDF]

Sci Rep
Younesi M, Mohsenzadeh Y.
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Positive experiences of medication self-management among older adults with chronic multimorbidities in Chinese city communities: a qualitative study. [PDF]

BMJ Open
Yang X, Wang XF, Su LL, Lv XC, Zhang CH, Zhang X.   +5 more
europepmc   +1 more source

Computer Vision for Autonomous Drill Jumbos: Detecting Non-Drillable Areas of a Mine Face. [PDF]

Sensors (Basel)
Rösgen M, Pekarski A, Ziegler M, Clausen E.   +3 more
europepmc   +1 more source

Phenomenological exploration of perceptions, experiences, facilitators, and inhibitors in patients with knee osteoarthritis during physiotherapy rehabilitation in a low- and middle-income country. [PDF]

BMC Musculoskelet Disord
Bathran C, Samuel AJ.
europepmc   +1 more source

Mapping the evidence base of positive psychology interventions: effectiveness, limitations, and future directions. [PDF]

Front Psychol
Akhter S, Kumar T, Shaheen M.
europepmc   +1 more source