Results 91 to 100 of about 1,511,858 (279)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Dimension of the set of positive solutions to nonlinear equations and applications

Electronic Journal of Differential Equations, 2016
We study the covering dimension of the set of (positive) solutions to various classes of nonlinear equations involving condensing and A-proper maps. It is based on the nontriviality of the fixed point index of a certain condensing map or on oddness ...
Petronije S. Milojevic
doaj  

Irreducible positive linear maps on operator algebras [PDF]

Proceedings of the American Mathematical Society, 1996
Motivated by the classical results of G. Frobenius and O. Perron on the spectral theory of square matrices with nonnegative real entries, D. Evans and R. Høegh-Krohn have studied the spectra of positive linear maps on general (noncommutative) matrix algebras.
openaire   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The interdependence of mid-trimester blood pressure and glucose levels in shaping fetal growth and neonatal outcomes: implications for risk–benefit assessment and co-management

BMC Medicine
Background Maternal hypertension and hyperglycemia are closely related but have distinct impacts on fetal growth and are managed independently. How the interdependence of blood pressure (BP) and glucose levels quantitatively influences risk patterns for ...
Lijuan Lv, Jingbo Yang, Linjie Li, Chuanyi Huang, Huihua Shi, Yiwen Fang, Lushu Zuo, Ting Liu, Hongli Duan, Jiying Wen, Qing Yang, Amanda Henry, Cha Han, Aihua Yin, Xin Zhou   +14 more
doaj   +1 more source

Detection of prospective areas for mineralization deposits using image analysis technique of aeromagnetic data around Marsa Alam-Idfu road, Eastern Desert, Egypt

Egyptian Journal of Petroleum, 2019
Area around Marsa Alam-Idfu road is considered as one of the most prospective regions for gold and base metals mineralization in Egypt. The total intensity aeromagnetic reduced to northern magnetic pole (RTP) data of such area revealed that a set of ...
A.S.M. Assran, R.A.Y. El Qassas, M.H.M. Yousef   +2 more
doaj   +1 more source