Results 211 to 220 of about 10,020,003 (308)

Sex-specific mediating role of serum uric acid in the association between dietary diversity and muscle strength in urban community-dwelling older adults. [PDF]

Front Public Health
Chu X, Zhao Y, Wang X, Ruan Y, Wang L, Wang F, Liu G, Yu D, Liu K, Tao F, Ruan L.   +10 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Neuroimaging Epicenters as Vulnerable Nodes in Plasma p-tau217/Aβ42-Positive Alzheimer's Disease. [PDF]

Research (Wash D C)
Li Q, Liu Y, Chen Q, Li X, Zhu Y, Deng Q, Zhang X, Chen F, Zhang Y, Ge D, Jiang Z, Wu X, Zhang W, Lu J, Zhang B.   +14 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Cardiac remodelling and dysfunction in cancer patients receiving cardiotoxic therapies: proteomic and metabolomic profiling. [PDF]

Eur Heart J
Ky B, Xia C, Ko K, Hyde C, Smith AM, Rhee JW, Tow-Keogh C, Tierney C, Long T, Zhang L, Liu PP, Wilcox NS, Dang V, Armenian SH, Jain M, Mangipudy R, Vaidya VS.   +16 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Is resting muscle sympathetic nerve activity related to peripheral or cerebrovascular haemodynamics at high altitude? A retrospective analysis. [PDF]

Exp Physiol
MacDonald TJA, McCrone JC, Osei-Boateng C, Wideman CD, Tsioros SL, Tremblay JC, Patrician A, Howe CA, Coombs GB, Stacey BS, Simpson LL, Stembridge M, Steinback CD, Moore JP, Gibbons TD, Hoiland RL, Villafuerte F, Moralez G, Ainslie PN, Tymko MM.   +19 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Cortical thickness changes precede high levels of amyloid by at least 7 years. [PDF]

Nat Neurosci
Roe JM, Jagust WJ, Landau SM, Harrison TM, Grydeland H, Slivka M, Alatorre-Warren JL, Garrido PF, Sørensen Ø, Grødem EOS, Ward TJ, Leonardsen EH, Murphy A, Lee J, Fladby T, Bjørnerud A, Walhovd KB, Fjell AM, Vidal-Piñeiro D, Wang Y.   +19 more
europepmc   +1 more source