Results 221 to 230 of about 1,333,113 (282)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Spatio-Temporal Modeling of Land-Use/Land-Cover Change and Land Surface Temperature Using SVM and CA-Markov in Dilla Town, Ethiopia. [PDF]

Glob Chall
Kebede TA, Gebremariam WH, Bogale HY, Reda TM, Jothimani M.   +4 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

In-vivo histology of Parkinson's disease using quantitative multiparametric mapping. [PDF]

NPJ Parkinsons Dis
Pokotylo MM, Göttlich M, Schmidt L, Weingarten HS, Dirksen L, Albrecht L, Griebner N, Uter J, Henkel J, Brüggemann N, Prasuhn J.   +10 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

A Machine Learning-Based Dynamic SST Index for Long-Lead Malaria Prediction in the Peruvian Amazon. [PDF]

Geohealth
Pan M, Hu S, Janko MM, Zaitchik BF, Takahashi K, Lescano AG, Munayco CV, Pan WK.   +7 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Dorsal-ventral precuneus gradients organise large-scale networks and track consciousness level

Lu D, Ram A, Carhart-Harris R, Roseman L, Owen A, Naci L, Menon D, Stamatakis E.   +7 more
europepmc   +1 more source

Diffusion kurtosis imaging detects cortical microstructural alterations in amyloid-positive MCI patients. [PDF]

Front Dement
Nielsen RB, Parbo P, Ismail R, B Dalby R, Tietze A, Brændgaard H, Gottrup H, Brooks DJ, Østergaard L, Eskildsen SF.   +9 more
europepmc   +1 more source