Results 141 to 150 of about 8,509,903 (292)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Positive almost periodic solutions to integral equations with superlinear perturbations via a new fixed point theorem in cones

open access: yesElectronic Journal of Differential Equations, 2017
In this article, we establish a new fixed point theorem for nonlinear operators with superlinear perturbations in partially ordered Banach spaces, Then we use the fixed point theorem to prove the existence of positive almost periodic solutions to ...
Jing-Yun Zhao   +2 more
doaj  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Positive periodic solutions for a predator-prey model with time delays and impulsive effect

open access: yesElectronic Journal of Differential Equations, 2008
In this article, a two-species predator-prey model with time delays and impulsive effect is investigated. By using Mawhin's continuation theorem of coincidence degree theory, sufficient conditions are obtained for the existence of positive periodic ...
Yongkun Li, Shan Gao
doaj  

Protocol for quantifying miRNA trafficking across the endosomal membrane

open access: yesFEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh   +2 more
wiley   +1 more source

Strongly stable algorithm for computing periodic system zeros [PDF]

open access: yes, 2003
We propose a computationally efficient and numerically reliable algorithm to compute the finite zeros of a linear discrete-time periodic system. The zeros are defined in terms of the transfer-function matrix corresponding to an equivalent lifted time ...
Varga, Andras
core  

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

open access: yesFEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta   +7 more
wiley   +1 more source

Square-Root Balancing and Computation of Minimal Realizations of Periodic Systems [PDF]

open access: yes, 1998
We propose a numerically reliable approach for balancing and minimal realization of linear periodic systems with time-varying dimensions. The proposed approach to balancing belongs to the family of square-root methods with guaranteed enhanced ...
Varga, A.
core  

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