Results 51 to 60 of about 96,168 (247)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Positive periodic solutions of singular systems
, 2010 The existence and multiplicity of positive periodic solutions for second order non-autonomous singular dynamical systems are established with superlinearity or sublinearity assumptions at infinity for an appropriately chosen parameter. Our results provide a unified treatment for the problem and significantly improve several results in the literature ...
openaire +2 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
New results on positive almost periodic solutions for first-order neutral differential equations
Advances in Difference Equations, 2018 In this paper, a class of first-order neutral differential equations with time-varying delays and coefficients is considered. Some results on the existence of positive almost periodic solutions for the equations are obtained by using the contracting ...
Yuehua Yu, Shuhua Gong
doaj +1 more source
Positive periodic solutions of functional differential equations
Journal of Differential Equations, 2004 The author considers the existence, multiplicity and nonexistence of positive \(\omega\)-periodic solutions for the periodic equation \[ x'(t)=a(t)g(x(t))x(t)-\lambda b(t)f(x(t-\tau(t))), \] where \(\lambda>0\) is a positive parameter, \(a,b\in C(\mathbb{R}\to [0,\infty))\) are \(\omega\)-periodic, \(\int_0^\omega a(t)\,dt>0\), \(\int_0^\omega b(t)\,dt>
openaire +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
New results for Brillouin electron beam focusing system
Boundary Value Problems, 2017 An experimental conjecture on the existence of positive periodic solutions for the Brillouin electron beam focusing system x ″ + a ( 1 + cos 2 t ) x = 1 x $x''+a(1+\cos 2t)x=\frac{1}{x}$ for a ∈ ( 0 , 1 2 ) $a\in(0,\frac{1}{2})$ is proved by applications
Zhibo Cheng, Shaowen Yao
doaj +1 more source