Results 101 to 110 of about 524,417 (274)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Existence of Almost-Periodic Solutions for Lotka-Volterra Cooperative Systems with Time Delay
Journal of Applied Mathematics, 2012 This paper considers the existence of positive almost-periodic solutions for almost-periodic Lotka-Volterra cooperative system with time delay. By using Mawhin’s continuation theorem of coincidence degree theory, sufficient conditions for the existence ...
Kaihong Zhao
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Positive almost periodic solutions for state-dependent delay Lotka-Volterra competition systems
Electronic Journal of Differential Equations, 2012 In this article, using Mawhin's continuation theorem of coincidence degree theory, we obtain sufficient conditions for the existence of positive almost periodic solutions for the system of equations $$ dot{u}_i(t)=u_i(t)Big[r_i(t)-a_{ii}(t)u_i(t ...
Yongkun Li, Chao Wang
doaj
On the Dynamics of the Recursive Sequence
Discrete Dynamics in Nature and Society, 2012 We investigate the boundedness character, the oscillatory, and the periodic character of positive solutions of the difference equation , where , , and the initial conditions are arbitrary positive numbers.
Mehmet Gümüş +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Positive periodic solutions of second-order nonlinear neutral differential equations with variable coefficients [PDF]
Mathematica Moravica, 2018 In this paper, we use Krasnoselskii's fixed point theorem to establish the existence of positive periodic solutions of second-order nonlinear neutral differential equations.
Hocine Gabsi +2 more
doaj
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Periodic solutions for a coupled pair of delay difference equations
Advances in Difference Equations, 2005 Based on the fixed-point index theory for a Banach space, positive periodic solutions are found for a system of delay difference equations. By using such results, the existence of nontrivial periodic solutions for delay difference equations with positive
Sui Sun Cheng +2 more
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source