Results 81 to 90 of about 524,417 (274)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
, 2015 We prove the existence of positive periodic solutions for the second order nonlinear equation $u" + a(x) g(u) = 0$, where $g(u)$ has superlinear growth at zero and at infinity. The weight function $a(x)$ is allowed to change its sign.
Feltrin, Guglielmo, Zanolin, Fabio
core
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Abstract and Applied Analysis, 2013 This paper presents a new generalized model of hematopoiesis with multiple time-varying delays. The main purpose of this paper is to study the existence and the global exponential stability of the positive pseudo almost periodic solutions, which are more
Junxia Meng
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Positive Solutions for Nonlinear Differential Equations with Periodic Boundary Condition
Journal of Applied Mathematics, 2012 We study the existence of positive solutions for second-order nonlinear differential equations with nonseparated boundary conditions. Our nonlinearity may be singular in its dependent variable.
Shengjun Li, Li Liang, Zonghu Xiu
doaj +1 more source
Three positive solutions for second-order periodic boundary value problems with sign-changing weight
Boundary Value Problems, 2018 In this paper, we study the global structure of positive solutions of periodic boundary value problems {−u″(t)+q(t)u(t)=λh(t)f(u(t)),t∈(0,2π),u(0)=u(2π),u′(0)=u′(2π), $$\textstyle\begin{cases} -u''(t)+q(t)u(t)=\lambda h(t)f(u(t)), \quad t\in (0,2\pi ), \\
Zhiqian He, Ruyun Ma, Man Xu
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source