Results 201 to 210 of about 4,116,426 (324)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Bone mineral density assessment according to Italian essential assistance levels: a positive predictive value analysis based on administrative data. [PDF]

Front Endocrinol (Lausanne)
Abate V, Vergatti A, Cavati G, Magelli S, Varriale A, Merlotti D, De Filippo G, Piccinocchi G, D'Elia L, Gennari L, Rendina D.   +10 more
europepmc   +1 more source

Multitarget Stool DNA Testing Has High Positive Predictive Value for Colorectal Neoplasia on the Second Round of Testing. [PDF]

Clin Gastroenterol Hepatol, 2023
Voss JK, Ebner DW, Burger KN, Mahoney DW, Devens ME, Lowrie KL, Kisiel JB.   +6 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Atrial fibrillation detection in endurance athletes vs non-athletes: Positive predictive value and burden estimation using implantable cardiac monitors. [PDF]

Heart Rhythm O2
Letnes JM, Sellevold AB, Apelland T, Brown FP, Byrkjeland R, Flasnes M, Loennechen JP, Nes BM, Myrstad M, NEXAF Investigators.   +9 more
europepmc   +1 more source

Positive predictive value of a single nucleotide polymorphism (SNP)-based NIPT for aneuploidy in twins: Experience from clinical practice. [PDF]

Prenat Diagn, 2022
Kantor V, Mo L, DiNonno W, Howard K, Palsuledesai CC, Parmar S, Chithiwala Z, Jelsema R, Xu W, Hedriana HL.   +9 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence.

Clinical Infectious Diseases, 2015
Paul M. Lantos, J. Branda, J. Boggan, S. Chudgar, E. A. Wilson, F. Ruffin, V. Fowler, P. Auwaerter, L. Nigrovic   +8 more
semanticscholar   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Determining the origin of genome aberrations improves the positive predictive value of NIPT for 22q11.2 deletion syndrome. [PDF]

Sci Rep
Xiang J, Sun X, Peng J, Zhang H, Shen J, Li J, Li H, Hu L, Zhang J, Zhou S, Xu S, Yang Y, He J, Peng Z.   +13 more
europepmc   +1 more source