Results 221 to 230 of about 4,116,426 (324)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Reply to Letter to the Editor: "Importance of Pretest Probability for Calculating Positive Predictive Value". [PDF]

Anatol J Cardiol
Erol S, Gürün Kaya A, Arslan F, Ayöz S, Gürsoy Çoruh A, Kul M, Özçınar E, Çiledağ A, Önen ZP, Kaya A, Özdemir Kumbasar Ö, Konstantinides SV.   +11 more
europepmc   +1 more source

Positive Predictive Value of Rapid Antigen Tests in School During SARS-CoV-2 Omicron Variant Surge. [PDF]

Pediatr Infect Dis J, 2023
Jang EJ, Choe YJ, Yun GW, Kim RK, Jeong H, Lee S, Park YJ.   +6 more
europepmc   +1 more source

Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial.

The Lancet Oncology, 2010
K. Albain, W. Barlow, S. Shak, G. Hortobagyi, R. Livingston, I. Yeh, P. Ravdin, R. Bugarini, F. Baehner, N. Davidson, G. Sledge, Eric P. Winer, C. Hudis, J. Ingle, E. Perez, K. Pritchard, L. Shepherd, J. Gralow, C. Yoshizawa, D. Allred, C. Osborne, D. Hayes   +21 more
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Paucibacillary Tuberculosis Drives the Low Positive Predictive Value of Xpert MTB/RIF Ultra for Rifampicin Resistance Detection in Low-Prevalence Settings. [PDF]

Clin Infect Dis
Cuella-Martin I, Hakizayezu F, Ahmed A, Runyambo D, Niyompano H, Keysers J, De Rijk WB, Mulders W, Mitchell EMH, Decroo T, Habimana YM, Migambi P, Muvunyi CM, de Jong BC, Rigouts L, Ngabonziza JCS.   +15 more
europepmc   +1 more source

High Positive Predictive Value of Multitarget Stool DNA After Aerodigestive Tract Radiotherapy. [PDF]

Gastro Hep Adv, 2022
Ebner DW, Eckmann JD, Burger KN, Mahoney DW, Whitaker TJ, Petersen IA, Kisiel JB.   +6 more
europepmc   +1 more source

Medicine's uncomfortable relationship with math: calculating positive predictive value.

JAMA Internal Medicine, 2014
A. Manrai, Gaurav Bhatia, Judith L. Strymish, I. Kohane, Sachin H Jain   +4 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Positive predictive value of cervical cancer screening results recommended for colposcopy by human papillomavirus vaccination status at 3 U.S. healthcare systems. [PDF]

Cancer Causes Control
Pocobelli G, Lykken J, Haas JS, Tiro J, Doria-Rose VP, Hyun N, Silver MI, Kamineni A, Chubak J.   +8 more
europepmc   +1 more source