Results 271 to 280 of about 4,110,990 (410)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Part 2: Positive and negative predictive values of diagnostic tests

Emergency, 2015
Saeed Safari, Alireza Baratloo, Mohamed Elfil, Ahmed Said Negida   +3 more
doaj  

Factors for increasing positive predictive value of pneumothorax detection on chest radiographs using artificial intelligence. [PDF]

Sci Rep
Lee S, Kim EK, Han K, Ryu L, Lee EH, Shin HJ.   +5 more
europepmc   +1 more source

Posterior hip capsular tenderness test improved the sensitivity and positive predictive value of FADIR test in diagnosing femoroacetabular impingement. [PDF]

Chin Med J (Engl), 2022
Gao G, Wang C, Wang J, Ao Y, Xu Y.
europepmc   +1 more source

Positive predictive value of a case definition for diabetes mellitus using automated administrative health data in children and youth exposed to antipsychotic drugs or control medications: a Tennessee Medicaid study [PDF]

, 2012
William V. Bobo, William O. Cooper, C. Michael Stein, Mark Olfson, Jackie Mounsey, James R. Daugherty, Wayne A. Ray   +6 more
openalex   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

A New Blood-Based Epigenetic Diagnostic Biomarker Test (EpiSwitch^®® NST) with High Sensitivity and Positive Predictive Value for Colorectal Cancer and Precancerous Polyps. [PDF]

Cancers (Basel)
Hunter E, Alshaker H, Weston C, Issa M, Bautista S, Gebregzabhar A, Virdi A, Dring A, Powell R, Green J, Lal R, Velchuru V, Aryal K, Bin Abu Hassan MR, Meng GT, Patel JS, Mohamed Gani SP, Lim CR, Guiel T, Akoulitchev A, Pchejetski D.   +20 more
europepmc   +1 more source

Positive Predictive Value of MOG-IgG for Clinically Defined MOG-AD Within a Real-World Cohort. [PDF]

Front Neurol, 2022
Manzano GS, Salky R, Mateen FJ, Klawiter EC, Chitnis T, Levy M, Matiello M.   +6 more
europepmc   +1 more source

Positive Predictive Value of French Hospitalization Discharge Codes for Stroke and Transient Ischemic Attack

European Neurology, 2015
M. Giroud, M. Hommel, E. Benzenine, J. Fauconnier, Y. Béjot, C. Quantin   +5 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source