Results 71 to 80 of about 3,224,102 (366)

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Accuracy of ultrasonography in the evaluation of abdominal masses in children in Nigeria

African Journal of Paediatric Surgery, 2019
Introduction: Abdominal masses in children constitute a spectrum of lesions of diverse origin, nature and significance. In a low-income setting with limited investigative facilities, accurate diagnosis of abdominal masses can be very challenging. However,
Adebayo Ayokunle Adedayo, Joseph Bako Igashi, Philip Mari Mshelbwala, Abdulrashid A Nasir, Emmanuel A Ameh, James O Adeniran   +5 more
doaj   +1 more source

Improving the Positive Predictive Value of Non-Invasive Prenatal Screening (NIPS). [PDF]

PLoS ONE, 2017
We evaluated performance characteristics of a laboratory-developed, non-invasive prenatal screening (NIPS) assay for fetal aneuploidies. This assay employs massively parallel shotgun sequencing with full automation.
Charles M Strom, Ben Anderson, David Tsao, Ke Zhang, Yan Liu, Kayla Livingston, Christopher Elzinga, Matthew Evans, Quoclinh Nguyen, David Wolfson, Charles Rowland, Paula Kolacki, Megan Maxwell, Jia-Chi Wang, Douglas Rabin, Joseph Catanese, Renius Owen, Corey Braastad, Weimin Sun   +18 more
doaj   +1 more source

Medicine's uncomfortable relationship with math: calculating positive predictive value.

JAMA Internal Medicine, 2014
In 1978, Casscells et al1 published a small but important study showing that the majority of physicians, house officers, and students overestimated the positive predictive value (PPV) of a laboratory test result using prevalence and false positive rate ...
A. Manrai, Gaurav Bhatia, Judith L. Strymish, I. Kohane, Sachin H Jain   +4 more
semanticscholar   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Accuracy of Leukocyte Esterase Reagent Strip (LERS) test for rapid bedside screening of spontaneous bacterial peritonitis: An observational study

Journal of Family Medicine and Primary Care, 2020
Introduction: Spontaneous bacterial peritonitis (SBP) is a frequent and severe complication in cirrhotic patients with ascites. SBP is generally diagnosed based on an increased number of polymorphonuclear neutrophils in the ascitic fluid (>250/mm3) and ...
Harshad Khairnar, Meghraj Ingle, Vikas Pandey, Kailash Kolhe, Shamsher Chauhan, Prabha Sawant, Swapnil Walke, Vipul Chaudhary   +7 more
doaj   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

A comparative analysis of the different HIV testing techniques used in Zambia: data from a clinical performance study

BMC Research Notes
Background Approximately 40 million people globally are living with HIV (PLWH) and more than 50% of these PLWH reside in Eastern and Southern Africa. Zambia has an adult HIV-1 prevalence (ages 15–49) of 11.1 [10.5–11.6] %, among the highest in the world (
Loveness Mukuka, Andros Theo, Precious Simushi, Mowa Zambwe, Peter J. Chipimo   +4 more
doaj   +1 more source

Predictive Modeling: An Optimized and Dynamic Solution Framework for Systematic Value Investing [PDF]

arXiv, 2017
This paper defines systematic value investing as an empirical optimization problem. Predictive modeling is introduced as a systematic value investing methodology with dynamic and optimization features. A predictive modeling process is demonstrated using financial metrics from Gray & Carlisle and Buffett & Clark.
arxiv