Results 51 to 60 of about 578,949 (401)

The Esophageal Pressure-Guided Ventilation 2 (EPVent2) trial protocol: a multicentre, randomised clinical trial of mechanical ventilation guided by transpulmonary pressure [PDF]

, 2014
Introduction: Optimal ventilator management for patients with acute respiratory distress syndrome (ARDS) remains uncertain. Lower tidal volume ventilation appears to be beneficial, but optimal management of positive end-expiratory pressure (PEEP) remains
Banner-Goodspeed, Valerie M, Fish, Emily, Loring, Stephen, Novack, Victor, Sarge, Todd, Talmor, Daniel   +5 more
core   +1 more source

Positive End‐Expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers

American Journal of Respiratory and Critical Care Medicine, 2018
Rationale: Diaphragm weakness in critically ill patients prolongs ventilator dependency and duration of hospital stay and increases mortality and healthcare costs.
J. Lindqvist, Marloes van den Berg, Robbert J. van der Pijl, P. Hooijman, A. Beishuizen, J. Elshof, M. D. de Waard, A. Girbes, A. S. Spoelstra-de Man, Zhong-Hua Shi, Charissa E van den Brom, S. Bogaards, Shengyi Shen, J. Strom, H. Granzier, J. Kole, R. Musters, M. Paul, L. Heunks, C. Ottenheijm   +19 more
semanticscholar   +1 more source

Noninvasive positive-pressure ventilation in clinical practice at a large university-affiliated Brazilian hospital

Clinics, 2012
OBJECTIVES: To describe noninvasive positive-pressure ventilation use in intensive care unit clinical practice, factors associated with NPPV failure and the associated prognosis. METHODS: A prospective cohort study.
Liria Yuri Yamauchi, Teresa Cristina Francischetto Travaglia, Sidnei Ricardo Nobre Bernardes, Maise C. Figueiroa, Clarice Tanaka, Carolina Fu   +5 more
doaj   +1 more source

Glomerular filtration is reduced by high tidal volume ventilation in an in vivo healthy rat model [PDF]

, 2009
Mechanical ventilation has been associated with organ failure in patients with acute respiratory distress syndrome. The present study examines the effects of tidal volume (V T) on renal function using two V T values (8 and 27 mL/kg) in anesthetized ...
ANDRADE, L., LUQUE, A., SANCHES, T.R., SEGURO, A.C., SHIMIZU, M.H.M.   +4 more
core   +2 more sources

Lung Rest During Extracorporeal Membrane Oxygenation for Neonatal Respiratory Failure-Practice Variations and Outcomes. [PDF]

, 2017
OBJECTIVE: Describe practice variations in ventilator strategies used for lung rest during extracorporeal membrane oxygenation for respiratory failure in neonates, and assess the potential impact of various lung rest strategies on the duration of ...
Aghai, Zubair H., Alapati, Deepthi, Dirnberger, Daniel R, Hossain, Jobayer, Ogino, Mark T., Shaffer, Thomas H.   +5 more
core   +1 more source

Lung stress and strain calculations in mechanically ventilated patients in the intensive care unit [PDF]

, 2016
Background Stress and strain are parameters to describe respiratory mechanics during mechanical ventilation. Calculations of stress require invasive and difficult to perform esophageal pressure measurements.
Bikker, I.G. (Ido), Blankman, P. (Paul), Gommers, D.A.M.P.J. (Diederik), Hasan, D. (Djo)   +3 more
core   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

The long-term outcomes of preterm infants receiving non-invasive high-frequency oscillatory ventilation

Frontiers in Pediatrics, 2022
ObjectiveTo investigate the clinical outcomes of preterm infants who received non-invasive high-frequency oscillatory ventilation following extubation in a neonatal intensive care unit.MethodsInfants born between 25 and 34 weeks of gestation with a birth
Yan Li, Yan Li, Yan Mo, Yan Mo, Liping Yao, Liping Yao, Qiufen Wei, Qiufen Wei, Danhua Meng, Danhua Meng, Wei Tan, Wei Tan, Xinnian Pan, Xinnian Pan   +13 more
doaj   +1 more source

Perfusion of the interventricular septum during ventilation with positive end-expiratory pressure (PEEP) [PDF]

, 1991
Objective: To determine whether regional hypoperfusion of the interventricular septum occurs during ventilation with positive end-expiratory pressure. Design: Animal study. Animals: Anesthetized, closed chest dogs (n = 8).
Iber, Volker, Messmer, Konrad, Schosser, Rudolf, Schwickert, Christiane, Spengler, Peter, Weiss, Michaela, Zwißler, Bernhard   +6 more
core  

BCS1L‐Associated Disease: 5′‐UTR Variant Shifts the Phenotype Towards Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the consequences of a pathogenic missense variant (c.838C>T; p.L280F) and a 5′‐UTR regulatory variant (c.‐122G>T) in BCS1L on disease pathogenesis and to understand how regulatory variants influence disease severity and clinical presentation.
Rotem Orbach, Nunziata Maio, Russell J. Butterfield, A. Reghan Foley, Sarah Silverstein, Yan Li, Katherine Chao, Tanya J. Lehky, Abigail Potticary, Tracey A. Rouault, Sandra Donkervoort, Carsten G. Bönnemann   +11 more
wiley   +1 more source