Results 151 to 160 of about 2,193,779 (340)

Personal Resilience in the Midst of Crisis: Empirical Findings From Positive Psychology [PDF]

open access: yes, 2009
resiliencepositive psychologylife stressorsPeople vary in their resilience in response to personal crises. A relatively new science entitled positive psychology offers some suggestions for ways to improve one's own resilience. This science uses empirical

core  

Single‐Cell RNA Sequencing of Thyroid Tissues Reveals Pathogenesis of Graves' Disease

open access: yesAdvanced Science, EarlyView.
Using single‐cell RNA sequencing and TCR profiling, this study constructed an immune cell atlas in thyroid tissue of Graves’ disease (GD), revealing dominant IFN‐γ‐secreting CD4+ T cells, expanded Tph and CD11c+ B cells, and enriched T/NK cells. Notably, GD thyroid follicular cells (TFCs) activated γδ T cells, which recruited cDC1 cells, suggesting a ...
Xiaoyi Zhou   +18 more
wiley   +1 more source

Asymmetries in information processing in a decision theory framework [PDF]

open access: yes
Research in psychology suggests that some individuals are more sensitive to positive than to negative information while others are more sensitive to negative rather than positive information.
Santos-Pinto, Luís
core   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

open access: yesAdvanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong   +5 more
wiley   +1 more source

A Field‐Deployable RotEx‐LAMP‐LFA Platform for Molecular Triage of HPV‐Driven Oncogenesis

open access: yesAdvanced Science, EarlyView.
This study presents RotEx‐LAMP‐LFA, a fully integrated, battery‐powered, low‐cost point‐of‐care device for rapid cervical cancer risk detection based on HPV16/18 E6/E7 mRNA. Clinically validated, the system demonstrated high sensitivity and specificity, and showed full concordance between self‐collected and clinician‐collected samples, offering a ...
Yuan Gao   +10 more
wiley   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

Quantum-like modeling of the order effect in decision making: POVM viewpoint on the Wang-Busemeyer QQ-equality

open access: yes, 2018
In recent years, quantum mechanics has been actively used in areas outside of physics, such as psychology, sociology, theory of decision-making, game theory, and others.
Khrennikov, Andrei, Lebedev, Aleksandr
core  

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