Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms
Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger +5 more
wiley +1 more source
Analytical Impedance Model of T-II Composite-Core ECT Probe Using Truncated Region Eigenfunction Expansion. [PDF]
Zhang S.
europepmc +1 more source
Ultra‐Thin Tow‐Based Discontinuous Composites—Material Overview and Aspirations
Tow‐based discontinuous composites made from ultra‐thin tapes offer outstanding in‐plane mechanical properties. This material, inspired by Nacre, has high volume fraction of tapes exceeding 90 % and allows for quasi‐isotropic material plates less than 100 micrometer in thickness.
Ioannis Katsivalis +8 more
wiley +1 more source
Spatiotemporal Accumulation of Four Major Bioactive Compounds in <i>Zanthoxylum nitidum</i> Roots: Implications for Tissue-Specific Processing and Harvesting Strategies. [PDF]
Tian T +6 more
europepmc +1 more source
Beyond Primary Nucleation: Molecular Basis of Peptide Crystal Secondary Nucleation at Soft Interface
High spatiotemporal‐resolution atomic force microscopy directly resolved peptide secondary nucleation (SN) and growth characteristics and mechanisms on HOPG. The landscape of peptide nucleation sites, growth dynamics, molecular‐scale structures, phase transitions, and cross‐seeding processes were realized.
Linhao Sun +2 more
wiley +1 more source
Machine Learning-Assisted Evaluation of Topography-Dependent Cellular Responses in Meniscus-Mimetic Piezoelectric Nanofibrous Scaffolds. [PDF]
Kim JI +5 more
europepmc +1 more source
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park +5 more
wiley +1 more source
Thermodiffusion in aqueous alkali halide solutions from ambient to supercooled conditions: ion-specific, structural, and mass effects. [PDF]
Zhao G, Bresme F.
europepmc +1 more source
Systematic investigation of antibody orientation strategies in lateral flow immunoassays reveals that a para‐substituted (aminomethyl)phenylboronic acid mediated probe (P‐6) combined with a biotin‐streptavidin test‐line modification achieves a synergistic 14‐ to 19‐fold sensitivity gain over conventional conjugation. Furthermore, multiplexed detection,
Pin‐Hao Wang +5 more
wiley +1 more source
Generating solutions for charged compact configurations in f(R) gravity. [PDF]
Noureen I, Mardan SA, Zahra A, Anwar I.
europepmc +1 more source

