Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Sic Transit Gloria Mundi: A Mathematical Theory of Popularity Waves Based on a SIIRR Model of Epidemic Spread. [PDF]
Entropy (Basel)Vitanov NK, Dimitrova ZI.
europepmc +1 more source
On unbounded positive solutions of nonlinear differential equations with oscillating coefficients [PDF]
, 1989 Takaŝi Kusano, Marko Švec
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TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Protocol to study DNA strand breaks during development and apoptosis using in situ nick translation in Drosophila. [PDF]
STAR ProtocMaurya D, Mondal BC.
europepmc +1 more source
On positive solutions of semilinear periodic-parabolic problems [PDF]
, 1986 Peter Hess
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Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Remineralization of artificial caries lesions using casein phosphopeptide-amorphous calcium phosphate containing probiotic lozenge: an in vitro study. [PDF]
BMC Oral HealthAkbeyaz Şivet E, Kargül B.
europepmc +1 more source
Multiple positive solutions for a class of nonlinear boundary value problems
, 1977 K.J. Brown, Harun Budin
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