Results 191 to 200 of about 13,879,944 (380)
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
Existence of positive solutions for Kirchhoff problems
Electronic Journal of Differential Equations, 2015 We study problems for the Kirchhoff equation $$\displaylines{ -\Big(a+b\int_{\Omega}|\nabla u|^2dx\Big)\Delta u =\nu u^3+ Q(x)u^{q},\quad \text{in }\Omega, \cr u=0, \quad \text{on }\partial\Omega, }$$ where $\Omega\subset \mathbb{R}^3$ is a ...
Jia-Feng Liao, Peng Zhang, Xing-Ping Wu
doaj
A priori bounds for positive solutions of a semilinear elliptic equation [PDF]
, 1985 Chris Cosner, Klaus Schmitt
openalex +1 more source
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Positive solutions for superlinear Riemann-Liouville fractional boundary-value problems
Electronic Journal of Differential Equations, 2017 Using a perturbation argument, we establish the existence and uniqueness of a positive continuous solution for the following superlinear Riemann-Liouville fractional boundary-value problem $$\displaylines{ D^{\alpha }u( x) -u(x)\varphi (x,u(x))=0 ...
Imed Bachar +2 more
doaj
On Positive Solutions of Semilinear Elliptic Equations [PDF]
, 1987 E. N. Dancer, Klaus Schmitt
openalex +1 more source
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
An elliptic problem with arbitrarily small positive solutions
Electronic Journal of Differential Equations, 2000 We show that for each $lambda > 0$, the problem $-Delta_p u = lambda f(u)$ in $Omega$, $u = 0$ on $partial Omega$ has a sequence of positive solutions $(u_n)_n$ with $max_{Omega} u_n$ decreasing to zero.
Pierpaolo Omari, Fabio Zanolin
doaj
On the geometry of level sets of positive solutions of semilinear elliptic equations [PDF]
, 1988 Chris Cosner, Klaus Schmitt
openalex +1 more source
Molecular Oncology, EarlyView.Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric +11 more
wiley +1 more source