Results 201 to 210 of about 1,891,065 (248)

Forward and inverse optimality problems of bone adaptation at the homogenised RVE level. [PDF]

Biomech Model Mechanobiol
Zysset PK.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Positive solution for nonlinear elliptic equations on symmetric domains

Electronic Journal of Differential Equations
Luiz F. O. Faria, Marcelo Montenegro
doaj  

Enhanced supply selection for better initial basic feasible solutions in transportation problems. [PDF]

MethodsX
Bunyamin RF, Amaliah B, Saikhu A.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

<i>Candida</i>-mediated vertical transmission of <i>Helicobacter pylori</i> in C57BL/6J mice. [PDF]

World J Gastroenterol
Xu XL, Luo TT, Liu Q, Cui GZ, Wu DY, Wu XJ, Yang TX, Sun JC, Jian HF, Zhuo SW, Chen ZH.   +10 more
europepmc   +1 more source

Positioning solution in lunar mining

Today space mining is a one of most interesting investments which space agencies and private companies are dealing with. Space resources are excellent ore which can be used in space or be brought back to Earth. Application of new technologies and operational methodologies in terrestrial mining sector targets to obtain a beneficial outcome in a long ...
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Oligonucleotide-Driven Nanoparticle Biosensor for <i>Candida albicans</i> Detection in Vaginal Swabs. [PDF]

ACS Omega
Qiu L, de la Encarnacion C, Li Y, Yuan M, Cao J, Bao Q, Zhang L, Lu X, Cui X.   +8 more
europepmc   +1 more source