Results 51 to 60 of about 1,891,065 (248)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Positive Solutions of Superlinear Elliptic Equations
Journal of Functional Analysis, 1999 Let \(\Omega\subset \mathbb{R}^N\) be a bounded convex domain with smooth boundary \(\Omega\) and \(f: \mathbb{R}^+\to \mathbb{R}\) be a locally Lipschitz continuous function with \(f(0)\geq 0\). The elliptic problems \[ -\Delta u= f(u),\quad u>0,\quad x\in\Omega,\quad u= 0,\quad x\in\partial\Omega;\tag{1} \] and \[ -\Delta u=\lambda f(u),\quad u>0 ...
openaire +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Positive periodic solutions for second-order neutral differential equations with functional delay
Electronic Journal of Differential Equations, 2012 We use Krasnoselskii's fixed point theorem to prove the existence of positive periodic solutions of the second-order nonlinear neutral differential equation $$ frac{d^2}{dt^2}x(t)+p(t)frac{d}{dt}x(t)+q(t)x(t) =cfrac{d}{dt}x(t-au(t))+f(t,h(x(t)),g(x ...
Ernest Yankson
doaj
Positive solutions for nonvariational Robin problems
Asymptotic Analysis, 2018 We study a nonlinear Robin problem driven by the p-Laplacian and with a reaction term depending on the gradient (convection term). Using the theory of nonlinear operators of monotone-type and the asymptotic analysis of a suitable perturbation of the original equation, we show the existence of a positive smooth solution.
Papageorgiou, Nikolaos S. +2 more
openaire +4 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Bounded positive solutions of Schrödinger equations
Applied Mathematics Letters, 2004 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Positive solutions of a boundary value problem with integral boundary conditions
Electronic Journal of Differential Equations, 2011 We consider boundary-value problems studied in a recent paper. We show that some existing theory developed by Webb and Infante applies to this problem and we use the known theory to show how to find improved estimates on parameters $mu^*, lambda ...
Jeff R. L. Webb
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