Results 61 to 70 of about 1,891,065 (248)

Positive solutions of higher order fractional integral boundary value problem with a parameter

Nonlinear Analysis, 2019
In this paper, we study a higher-order fractional differential equation with integral boundary conditions and a parameter. Under different conditions of nonlinearity, existence and nonexistence results for positive solutions are derived in terms of ...
Xinan Hao, Luyao Zhang, Lishan Liu
doaj   +1 more source

Positive solutions to sublinear elliptic problems

Colloquium Mathematicum, 2019
Let $L$ be a second order elliptic operator $L$ with smooth coefficients defined on a domain $ $ in $\mathbb{R}^d $, $d\geq3$, such that $L1\leq 0$. We study existence and properties of continuous solutions to the following problem \begin{equation}\label{00} Lu= (\cdot,u),% & \hbox{in $ $; in the sens of distribution;} \\ \end{equation} in $ ,$
openaire   +3 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Positive solutions for multipoint boundary-value problem with parameters

Electronic Journal of Differential Equations, 2008
In this paper, we study a generalized Sturm-Liouville boundary-value problems with two positive parameters. By constructing a completely continuous operator and combining fixed point index theorem and some properties of the eigenvalues of linear ...
Zhongli Wei, Juanjuan Xu
doaj  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A topological analysis of p(x)-harmonic functionals in one-dimensional nonlocal elliptic equations

Advanced Nonlinear Studies
We consider a class of one-dimensional elliptic equations possessing a p(x)-harmonic functional as a nonlocal coefficient.
Goodrich Christopher S.
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Periodic boundary value problems for first order difference equations

Electronic Journal of Qualitative Theory of Differential Equations, 2012
In this paper, existence criteria for single and multiple positive solutions of some of periodic boundary value problems for first order difference equation \[\left\{\begin{array}{ll} \Delta x(k)+f(k,x(k+1))=0, & k\in \left[ 0,T\right] ,\\ x(0)=x(T+1), &
Wen Guan, Suang-Hong Ma, Da-Bin Wang
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Multiple positive solutions for second order impulsive differential equation

Electronic Journal of Qualitative Theory of Differential Equations, 2013
We investigate the existence of at least three positive solutions to a three-point boundary value problem of second order impulsive differential equation. Our analysis rely on the Avery-Peterson fixed point theorem in a cone.
Weihua Jiang, Qiang Zhang, Weiwei Guo
doaj   +1 more source