Results 161 to 170 of about 1,228,906 (333)

Global Positioning on Earth [PDF]

open access: yesarXiv
Contrary to popular belief, the global positioning problem on earth may have more than one solutions even if the user position is restricted to a sphere. With 3 satellites, we show that there can be up to 4 solutions on a sphere. With 4 or more satellites, we show that, for any pair of points on a sphere, there is a family of hyperboloids of revolution
arxiv  

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

open access: yesMolecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Positive solutions for a nonlocal boundary-value problem with vector-valued response

open access: yesElectronic Journal of Differential Equations, 2002
Using variational methods, we study the existence of positive solutions for a nonlocal boundary-value problem with vector-valued response. We develop duality and variational principles for this problem and present a numerical version which enables the ...
Andrzej Nowakowski, Aleksandra Orpel
doaj  

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