Results 171 to 180 of about 1,228,906 (333)

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Monotone iterative method for obtaining positive solutions of integral boundary-value problems with phi-Laplacian operator

Electronic Journal of Differential Equations, 2012
This article concerns the existence, multiplicity of positive solutions for the integral boundary-value problem with $phi$-Laplacian, $$displaylines{ ig(phi(u'(t))ig)'+f(t,u(t),u'(t))=0,quad tin[0,1],cr u(0)=int_0^1 u(r)g(r),dr,quad u(1)=int_0^1u(r)h(
Yonghong Ding
doaj  

Dynamic behavior of positive solutions for a leslie predator-prey system with mutual interference and feedback controls. [PDF]

ScientificWorldJournal, 2014
Zhang C, Huang NJ, Deng CX.
europepmc   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

xistence of solutions for p-Laplacian functional dynamic equations on time scales

Electronic Journal of Differential Equations, 2006
In this paper, the author studies boundary-value problems for p-Laplacian functional dynamic equations on a time scale. By using the fixed point theorem, sufficient conditions are established for the existence of positive solutions.
Changxiu Song
doaj  

Positive solutions and spectral properties of second order elliptic operators [PDF]

, 1981
W. Allegretto
openalex   +1 more source

Global asymptotic behaviour of positive solutions to a non-autonomous Nicholson's blowflies model with delays. [PDF]

J Biol Dyn, 2014
Van Hien L.
europepmc   +1 more source

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source

Multiple positive solutions for a class of quasilinear elliptic boundary-value problems

Electronic Journal of Differential Equations, 2003
Using variational arguments we prove some nonexistence and multiplicity results for positive solutions of a class of elliptic boundary-value problems involving the p-Laplacian and a parameter.
Kanishka Perera
doaj  

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source