Results 281 to 290 of about 1,228,906 (333)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Solutions behavior of mechanical oscillator equations with impulsive effects under Power Caputo fractional operator and its symmetric cases. [PDF]

Sci Rep
Saber H, Almalahi M, Bouye M, Aldwoah K, Moumen A, Muflh B.   +5 more
europepmc   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

The influence of psychosocial factors on productivity when implementing new office designs - a longitudinal explorative study in the Swedish public sector. [PDF]

BMC Public Health
Stöllman Å, Svartengren M, Lampa E, Nyman T.   +3 more
europepmc   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

A new intrusion detection method using ensemble classification and feature selection. [PDF]

Sci Rep
Doost PA, Moghadam SS, Khezri E, Basem A, Trik M.   +4 more
europepmc   +1 more source

Inhibitions imposed by kinetic constraints of membranes in all-solid-state ion-selective electrodes: characteristics of interfacial capacitance in solid contacts. [PDF]

Chem Sci
Xia RZ, Cai X, Lin JY, Zhao YH, Liu ZH, Wang CL, Chen SH, Yang M, Song ZY, Li PH, Huang XJ.   +10 more
europepmc   +1 more source

Phenoxazine Radical as a Positive Material for Neutral pH Aqueous Flow Batteries. [PDF]

ACS Appl Energy Mater
Martínez-González E, Tuna A, Peljo P.
europepmc   +1 more source

Localized Corrosion of CUSTOM 450 and AM 350 Stainless Steels in H₂SO₄ and NaCl Solutions. [PDF]

Materials (Basel)
Almeraya-Calderón F, Villegas-Tovar M, Maldonado-Bandala E, Lara-Banda M, Baltazar-Zamora MA, Landa-Ruiz L, Nieves-Mendoza D, Jaquez-Muñoz JM, Estupiñan-Lopez F, Cabral-Miramontes J, Olguin-Coca J, Gaona-Tiburcio C.   +11 more
europepmc   +1 more source

Ammonia sets limit to life and alters physiology independently of pH in Halomonas meridiana

Hopton CM, Nienow P, Cockell CS.
europepmc   +1 more source