Results 71 to 80 of about 15,587,481 (320)

On the existence of positive solutions and negative solutions of singular fractional differential equations via global bifurcation techniques

open access: yes, 2016
We are concerned with a type of fractional differential equations attached to boundary conditions. We investigate the existence of positive solutions and negative solutions via global bifurcation techniques.
Yongliang Guan, Zengqin Zhao, Xiuli Lin
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Positive solutions of integro-differential inequalities

open access: yesComputers & Mathematics with Applications, 1997
In the present paper, the authors have studied the nonexistence of positive solutions of the following integrodifferential inequalities \[ (-1)^{n+ 1}y^{(n)}(t)+ \int^t_0 f(t- s,y(s))ds\leq 0 \] on \([0,\infty)\) \((n = 1,2,4)\) assuming that the inequalities \[ -\lambda^n+ \int^\infty_0 e^{\lambda^s} K(s)ds> 0,\quad\text{for all }\lambda>0\quad (n= 1 ...
Ravi P. Agarwal   +2 more
openaire   +2 more sources

Positive Solutions of Semilinear Equations in Cones [PDF]

open access: yesTransactions of the American Mathematical Society, 1992
In this paper we consider the problem of finding a positive solution of the equation Δ u + | x | ν u ( n + 2 + 2
openaire   +2 more sources

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

Periodic positive solutions of superlinear delay equations via topological degree. [PDF]

open access: yesPhilos Trans A Math Phys Eng Sci, 2021
Amster P, Benevieri P, Haddad J.
europepmc   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

open access: yesFEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson   +7 more
wiley   +1 more source

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