Results 121 to 130 of about 2,937 (188)

Right Ventricular Dysfunction and Ventriculo‐Arterial Uncoupling in Heart Failure With Preserved Ejection Fraction: A Phenotype‐Specific Review of Mechanisms, Diagnosis, and Therapeutic Strategies

open access: yesClinical Cardiology, Volume 49, Issue 11, November 2026.
Right ventricular dysfunction affects 19%–33% of patients With heart failure With preserved ejection fraction and is associated With exercise intolerance, hospitalization, and mortality. Assessing right ventricular function and its coupling with the pulmonary circulation may improve risk stratification and support management tailored to distinct ...
Amarelle Chamoun   +13 more
wiley   +1 more source

From Biological Mechanisms to Causal Inference: Quantitative Systems Pharmacology and Causal Frameworks in Drug Development

open access: yesClinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1255-1265, November 2026.
Digital patients and in silico clinical trials offer new opportunities to advance pharmacological research, clinical development, and regulatory decision‐making by enabling the simulation of treatment effects prior to testing in patients. Among the most promising of these opportunities is the combined use of quantitative systems pharmacology (QSP) and ...
Thomas Klabunde   +3 more
wiley   +1 more source

The Effect of Acute Beetroot Juice and Caffeine Supplementation on Specific Judo Performance During a Simulated Competition Day in Judo Athletes

open access: yesEuropean Journal of Sport Science, Volume 26, Issue 11, November 2026.
ABSTRACT Beetroot juice (BJ) and caffeine (CAF) are well‐established ergogenic aids for exercise performance. However, little is known about their efficacy and interaction within the specific context of a judo competition day. This study investigated the acute effects of BJ, CAF, and their combination (BJCAF) on judo‐specific performance across a ...
Sefer Karabağ   +6 more
wiley   +1 more source

Agentic artificial intelligence in mechanics of materials: A review of building tailored models on demand

open access: yesGAMM-Mitteilungen, Volume 49, Issue 4, November 2026.
Abstract In mechanics of materials, many powerful methods are accessible only to experts. Constitutive models, for example, describe the relation between stress and strain in materials and are a core ingredient of simulations from structural engineering to biomechanics. Yet building and using such models requires specialized expertise—a barrier for the
Marius Tacke   +4 more
wiley   +1 more source

Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies

open access: yesMedComm, Volume 7, Issue 11, November 2026.
Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang   +4 more
wiley   +1 more source

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