Results 221 to 230 of about 534,367 (396)

Appraising the visibility, relevance and impacts of clinical pharmacology

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Clinical pharmacology (CP) used to be a strong medical and scientific field, but during the last three decades it seems to have lost some of its appeal. We reviewed the visibility, relevance and impact of CP and clinical pharmacologists across the globe and suggest ways to strengthen the discipline to address future pharmacotherapeutic challenges.
Serge Cremers   +5 more
wiley   +1 more source

Insulin resistance in liver cirrhosis. Positron-emission tomography scan analysis of skeletal muscle glucose metabolism. [PDF]

open access: bronze, 1993
O. Selberg   +7 more
openalex   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Wellenberg K. Simon   +7 more
wiley   +1 more source

The Curious Concept That Almost Nobody Seemed to Care About at First: Virtual Particles in the Post‐War Period**

open access: yesBerichte zur Wissenschaftsgeschichte, EarlyView.
Abstract Short‐lived, unobservable, and not subject to the usual rules of conservation of energy and momentum, virtual particles—an integral part of the conceptual framework of quantum field theory (QFT)—exhibit a number of curious characteristics which, in recent decades, have in part fueled important discussions about their ontological status ...
Jean‐Philippe Martinez
wiley   +1 more source

Memory Gate Controlled by Contexts: Potential Key Structure That Could Link Small Associative Failures With Severe Cognitive Disorders

open access: yesBioEssays, EarlyView.
Memory gate (MG) hypothesis assumes a neural structure that connects inputs to appropriate contexts. Panel A shows an input (green) that, in the MG, does not match the context (red): memory does not recognize it. Panel B shows that, in the MG, the context (green) matches the input: memory recognizes the pattern.
Eduardo Mizraji, Juan Lin, Andrés Pomi
wiley   +1 more source

Nanomaterials for enhanced X‐ray‐triggered cancer therapy: Progress and prospects

open access: yesBMEMat, EarlyView.
This review summarizes the latest progress in nanomaterials for X‐ray‐triggered cancer therapy, highlighting their various advantages such as targeted delivery, reduced side effects, and enhanced therapeutic efficacy. Abstract X‐rays, a form of ionizing radiation with high energy and significant penetration capability, are commonly used in clinical ...
Yuanchun Chen   +6 more
wiley   +1 more source

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