Results 271 to 280 of about 377,080 (350)

Merkel Cell Carcinoma: Evolving Therapeutics, Continued Challenges

Head &Neck, EarlyView.
ABSTRACT Background Merkel Cell Carcinoma (MCC) is a rare, aggressive neuroendocrine malignancy with rising incidence, influenced by ultraviolet (UV) radiation and Merkel cell polyomavirus (MCPyV). Methods This review summarizes recent advances in MCC management, based on an analysis of current literature, focusing on immune checkpoint inhibitors (ICIs)
Hunter A. Holley, Maria Lyons, Barry O'Sullivan, Neville Shine, Robbie Woods, Orla McArdle, James Paul O'Neill   +6 more
wiley   +1 more source

Pharmacokinetics of [ ¹⁸ F]Trovafloxacin in Healthy Human Subjects Studied with Positron Emission Tomography

, 1998
Alan J. Fischman, John W. Babich, Ali A. Bonab, Nathaniel M. Alpert, John Vincent, Ronald J. Callahan, John A. Correia, Robert H. Rubin   +7 more
openalex   +1 more source

Diagnostic Accuracy of HPV Circulating Tumor DNA Following Non‐Diagnostic FNA of a Cystic Lateral Neck Mass

Head &Neck, EarlyView.
ABSTRACT Background Cystic lateral neck masses in adults commonly represent nodal metastases from HPV‐associated oropharyngeal squamous cell carcinoma (OPSCC) or benign lesions. Because cystic lesions are relatively acellular, fine‐needle aspiration (FNA) is often non‐diagnostic.
Michael R. Papazian, Melanie D. Hicks, Kyle Mannion, Meghan Turner, Michael C. Topf   +4 more
wiley   +1 more source

In Vitro Evaluation of ¹¹C‐Labeled (S)‐Nicotine, (S)‐3‐Methyl‐5‐(1‐Methyl‐2‐Pyrrolidinyl)isoxazole, and (R,S)‐1‐Methyl‐2‐(3‐Pyridyl)azetidine as Nicotinic Receptor Ligands for Positron Emission Tomography Studies

, 1998
Wiebke Sihver, Karl‐Johan Fasth, Mattias Ögren, Håkan Bivehed, Mats Bergström, Agneta Nordberg, Yasuyoshi Watanabe, Bengt Långström   +7 more
openalex   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

The mechanisms in glucose metabolism of aging hippocampus

Ibrain, EarlyView.
Cognitive decline in elders stems from the irreversible loss and functional decline of neurons, with the hippocampus being particularly susceptible to age‐related neuronal deterioration. Glucose acts as the primary fuel for the brain, and a constant provision of glucose to the hippocampus is essential for memory and cognitive functions.
Rui He, Fuxing Zhao, Zhiyu Yang, Tingting Wang, Yaohui Zhang, Jinglan Quan, Gaohong Zhu   +6 more
wiley   +1 more source

Pitfall of false localization in basal temporal epilepsy: A clinical vignette

Epileptic Disorders, EarlyView.
Mathieu Dhoisne, Romain Carron, Fabrice Bartolomei, Stanislas Lagarde   +3 more
wiley   +1 more source

Recent applications of magnetic iron oxide nanoparticles for cerebral blood volume quantification in functional magnetic resonance imaging

Ibrain, EarlyView.
This study explores the recent advances in the use of iron oxide nanoparticles (IONPs) in functional MRI (fMRI) for studying brain functions, specifically cerebral blood volume (CBV) measurements. It covers fMRI techniques, magnetic nanoparticle synthesis, coating methods, and their applications in CBV imaging, in comparison to other contrast agents in
Giorgio Capuzzello, Antonella Antonelli, Rosaria Rinaldi, Riccardo Di Corato   +3 more
wiley   +1 more source

Incidence and temporal trends of depression and anxiety following cancer diagnosis in Japan: Insights from the LIFE study

International Journal of Cancer, EarlyView.
What's New? Depression and anxiety are common but often under‐recognized among cancer patients. Using claims data from 14 municipalities in Japan, this study clarified the incidence and temporal trends of these conditions following cancer diagnosis over a 24‐month follow‐up period.
Kengo Kawaguchi, Megumi Maeda, Fumiko Murata, Makoto Endo, Yasuharu Nakashima, Haruhisa Fukuda   +5 more
wiley   +1 more source

Impact of geriatric impairments on outcomes of single‐agent immunotherapy in solid tumors

International Journal of Cancer, EarlyView.
What's New? This study comprehensively assesses the impact of frailty and geriatric impairments on key clinical outcomes of single‐agent immunotherapy in older adults with solid tumors. Using prospective multicenter data, the authors demonstrate that frailty is significantly associated with higher rates of all‐cause hospitalization and mortality ...
Asli Özkan, Karlijn de Joode, Ellen Kapiteijn, Marije Slingerland, Stephanie Zunder, Frederiek van den Bos, Simon Mooijaart, Anna Uit den Boogaard, Stella Trompet, Hans Westgeest, Astrid van der Veldt, Ron H. J. Mathijssen, Geert Labots, Cynthia Holterhues, Els M. E. Verdegaal, Nienke A. de Glas, Johanneke E. A. Portielje   +16 more
wiley   +1 more source