Results 181 to 190 of about 337,692 (304)

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Deep learning-based susceptibility map-weighted imaging analysis of dorsal nigral hyperintensity as a surrogate for dopamine transporter positron emission tomography in patients with idiopathic rapid eye movement sleep behavior disorder. [PDF]

Front Neurol
Sohn B, Kim JR, Heo H, Song S, Kim EY, Joo EY.   +5 more
europepmc   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Cardiac Metastasis Mimicking Lateral STEMI in Small-Cell Lung Cancer. [PDF]

JACC Case Rep
Erdoğdu OU, Yılmaz Öztekin GM.
europepmc   +1 more source

Coronary Flow in Hypertrophic Obstructive Cardiomyopathy—Immediate Effects of Alcohol Septal Ablation

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Hypertrophic cardiomyopathy is associated with alterations in coronary microvascular function which have variable pathophysiologic mechanisms, and variable reversibility acutely and chronically following alcohol septal ablation (ASA).
Vojko V. Misevic, Ana N. Golocevac, Kosta S. Krupnikovic, Stefan B. Timcic, Natalija B. Arnautovic, Dragana D. Radoicic, Milan R. Dobric, Aleksandar D. Mandic, Stefan S. Zivkovic, Aleksa D. Obradovic, Vladimir D. Mihajlovic, Natalija R. Odanovic, Ivan S. Ilic   +12 more
wiley   +1 more source

Integrating Lymph Node Metastasis and Programmed Death-Ligand 1 Prediction in Non-Small Cell Lung Cancer From a Single PET/CT Scan: Multicenter Radiomics Study. [PDF]

JMIR Med Inform
Chen W, Liu Q, Peng H, Zhang J, Chen Z, Hu S, Song S.   +6 more
europepmc   +1 more source

Diagnostic Sensitivity of [18F]-Florbetaben-PET/CT in Detecting Cardiac Involvement in AL Amyloidosis: The Prospective MoRBiDA Study. [PDF]

JACC Adv
Milani P, Sanna GD, Pepe G, Valentini A, Matassa G, Guida G, Mussinelli R, Basset M, Turco A, Perlini S, Greco A, Schirinzi S, Nuvolone M, Bassi E, Zacchino M, Foli A, Merlini G, De Luca L, Preda L, Palladini G.   +19 more
europepmc   +1 more source

Do Brain Extracellular Fluid Concentrations Predict PET‐Inferred Receptor Occupancy in Human CNS? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands

Clinical Pharmacology &Therapeutics, EarlyView.
A mechanistic CNS PBPK model framework was applied to eight antipsychotic D2 receptor ligands, comparing brain extracellular fluid (brainECF) and brain cell membrane (brainM) as biophase for predicting human receptor occupancy compared against PET neuroimaging data. BrainM concentrations showed improved agreement with PET‐derived receptor occupancy for
Divakar Budda, J.G. Coen van Hasselt, Elizabeth C.M. de Lange   +2 more
wiley   +1 more source

Role of Positron Emission Tomography/Computed Tomography (PET/CT) in Detecting Metachronous Primary Tumors: Diagnostic and Clinical Implications From a Single-Patient Case. [PDF]

Cureus
Alharganee AZ, Mohammed ZA, Ashraf Kadhim A, Abdulrahman M.   +3 more
europepmc   +1 more source

Constructing an External Control Arm Using the French REALYSA Cohort to Replicate Outcomes of a Randomized Trial Arm in Advanced Hodgkin Lymphoma

Clinical Pharmacology &Therapeutics, EarlyView.
External control (EC) arms using routine data can be used as comparators in clinical trials under certain conditions. The objective of this study was to assess the ability of an EC arm to replicate outcomes of a randomized controlled trial (RCT) arm receiving the same treatment strategy in advanced stage classical Hodgkin lymphoma and serve as ...
Olivia Febvey‐Combes, Cédric Rossi, Behrouz Kassai, Tesla Murairi Mirimo, Loïc Chartier, Fanny Cherblanc, Emeline Cugnod, Hervé Ghesquières, Aurélien Belot   +8 more
wiley   +1 more source