Results 241 to 250 of about 528,348 (385)

Manganese Neurotoxicity and Familial Disorders of Manganese Transport

open access: yesAnnals of the Child Neurology Society, EarlyView.
ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley   +1 more source

Positron Emission Tomography. Usefulness in assessing myocardial viability.

open access: bronze, 1992
Hirofumi Kambara   +5 more
openalex   +2 more sources

A Randomized Thorough QT Trial Using Concentration‐QT Analysis to Evaluate the Effects of Centanafadine on Cardiac Repolarization

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Centanafadine is a norepinephrine/dopamine/serotonin reuptake inhibitor in development for treatment of attention‐deficit/hyperactivity disorder. This double‐blind, placebo‐ and moxifloxacin‐controlled, 3‐period crossover trial evaluated the effects of centanafadine (EB‐1020) and its metabolite (EB‐10601) on cardiac repolarization in 30 ...
Osman S. Turkoglu   +3 more
wiley   +1 more source

Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects.

open access: green, 1993
Stephen L. Dewey   +8 more
openalex   +1 more source

Nucleophilic Fluorination of a Secondary Alkyl Bromide with KF(18‐Crown‐6) and Bulky Diols: Microsolvation Causes Chemoselectivity Inversion in the Free Energy Profile

open access: yesChemPlusChem, EarlyView.
The combination of crown ether with strong hydrogen bond donor bulky diols enhances reactivity and SN2 selectivity in challenging fluorination reactions of secondary alkyl bromide substrates. Fluoride ion solvated in polar aprotic solvents works like bases and reacts with secondary alkyl bromide substrates mainly via E2 reactions, with minor formation ...
Luís F. Resende   +2 more
wiley   +1 more source

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