Results 151 to 160 of about 7,117,019 (296)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Kasei-Theory III.Ka: Ka Without Possibility

This paper fixes Ka within the third system of Kasei-Theory as a non-modal decompositional fixation without possibility. Ka is not introduced as possibility, modality, potentiality, capacity, capability, ability, optionality ...
Minamikata, Juza
core   +1 more source

Non-realist cognitivism, superassertibility and vicious regress. [PDF]

Synthese
Ferrie CP.
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Scenarios, probability and possible futures [PDF]

This paper provides an introduction to the mathematical theory of possibility, and examines how this tool can contribute to the analysis of far distant futures. The degree of mathematical possibility of a future is a number between O and 1. It quantifies
Minh Ha-Duong
core  

The power of theory in the life sciences. [PDF]

Elife
Fine JL, Creeggan F, Gertsvolf J, Gupta P, Groh AMR.   +4 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Place of possibility theory in transportation analysis

The transportation phenomena, as a manifestation of the complex human, social, economic, and political interactions, are filled with uncertainties. In order for the analysis of transportation to be scientifically credible, uncertainty must be accounted ...
Kikuchi, Shinya, Chakroborty, Partha
core  

Exploring the process of social support among parents of children with cancer in the sociocultural context of Iran: a grounded theory study protocol. [PDF]

BMJ Open
Galehdari Fard A, Habibzadeh H, Heydari H, Eghtedar S.   +3 more
europepmc   +1 more source