Results 111 to 120 of about 5,040,967 (335)
Parallel Lives: A Local-Realistic Interpretation of “Nonlocal” Boxes
Entropy, 2019 We carry out a thought experiment in an imaginary world. Our world is both local and realistic, yet it violates a Bell inequality more than does quantum theory.
Gilles Brassard, Paul Raymond-Robichaud
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A Coding Theoretic Study on MLL proof nets
, 2010 Coding theory is very useful for real world applications. A notable example is digital television. Basically, coding theory is to study a way of detecting and/or correcting data that may be true or false. Moreover coding theory is an area of mathematics,
Girard +4 more
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Sobre o conhecimento que a arte é
MatLit, 2015 This article aims to rethink the theory of contemporary art in the light of scientific concepts, establishing a possible structural correspondence between artistic invention and scientific invention. But it also aims to draw attention to the necessity of
Castro, E. M. de Melo e
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
On the methodology of possible worlds semantics. I. Correspondence theory.
Notre Dame Journal of Formal Logic, 1988 The first part of the paper summarizes work by Johan van Benthem on the relation between systems of modal logic and the possible-worlds structures which interpret them. Sometimes the fit is perfect, as in a case like the system T whose frames are precisely the reflexive frames, and which is characterized by those frames.
Pearce, David, Wansing, Heinrich
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source