Results 111 to 120 of about 12,774,178 (324)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Search for New Physics in rare decays at LHCb

, 2012
Rare heavy flavor decays provide stringent tests of the Standard Model of particle physics and allow to test for possible new Physics scenarios. The LHCb experiment at CERN is the ideal place for these searches as it has recorded the worlds largest ...
Aaij, Aaij, Aaij, Aaij, Aaij, Albrecht, Ali, Altmannshofer, Atre, Bediaga, Bobeth, Buras, de Bruyn, Feldmann, Johannes Albrecht, Junk, Kruger, Nakamura, Read, Shaposhnikov, Wei   +20 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

G.W. Leibniz’s Metaphysics in the Philosophy of Gilles Deleuze: From Ontology to Ethics

RUDN Journal of Philosophy
This study is a detailed analysis of the influence of the philosophy of G.W. Leibniz on the metaphysics and ethics of Gilles Deleuze, with a focus on the transformation of Leibniz’s key concepts within Deleuze’s philosophical system. Particular attention
Vladimir A. Tsvyk, Roman I. Mikhan
doaj   +1 more source

Online Computing Quantile Summaries Over Uncertain Data Streams

IEEE Access, 2019
Quantile summarization is a useful tool in data streams management and mining that can efficiently capture the distribution of the data. A quantile of a sequence of points is the point with a given rank in the sequence.
Chunquan Liang, Mei Li, Bin Liu
doaj   +1 more source

On not knowing one’s place [PDF]

, 2000
Ethnographers have described many cultural worlds of the Pacific with subtlety and energy, but those worlds were and are always more complex than most standard forms of ethnography have recognized.
Goldsmith, Michael
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source